BACKGROUND OF THE INVENTION

This invention relates to ureas and isoureas and in particular their use as agricultural chemicals and particularly as herbicides.

U.S. Pat. No. 4,127,405 teaches compounds which are useful for controlling weeds in wheat having the formula ##STR1## wherein ##STR2##

R.sub.3 and R.sub.6 are independently hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, nitro, trifluoromethyl, cyano, CH.sub.3 S(O).sub.n --or CH.sub.3 CH.sub.2 S(O).sub.n --;

R.sub.4 is hydrogen, fluorine, chlorine, bromine or methyl;

R.sub.5 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy;

R.sub.7 is hydrogen, fluroine, chlorine, bromine, alkyl of 1-2 carbon atoms or alkoxy of 1--2 carbon atoms;

R.sub.8 is hydrogen, methyl, chlorine or bromine;

R.sub.9 and R.sub.10 are independently hydrogen, methyl, chlorine or bromine;

W and Q are independently oxygen or sulfur; n is 0, 1 or 2;

X is hydrogen, chlorine, bromine, methyl, ethyl, alkoxy of 1--3 carbon atoms, trifluoromethyl, CH.sub.3 S--or CH.sub.3 OCH.sub.2 -; and

Y is methyl or methoxy; or their agriculturally suitable salts; provided that:

(a) when R.sub.5 is other than hydrogen, at least one of R.sub.3, R.sub.4, R.sub.6 and R.sub.7 is other than hydrogen and at least two of R.sub.3, R.sub.4, R.sub.6 and R.sub.7 must be hydrogen;

(b) when R.sub.5 is hydrogen and all of R.sub.3, R.sub.4, R.sub.6 and R.sub.7 are other than hydrogen, then all of R.sub.3, R.sub.4, R.sub.6 and R.sub.7 must be either chlorine or methyl; and

(c) when R.sub.3 and R.sub.7 are both hydrogen, at least one of R.sub.4, R.sub.5 or R.sub.6 must be hydrogen.

French Pat. No. 1,468,747 discloses the following para-substituted phenylsulfonamides, useful as antidiabetic agents: ##STR3## wherein R.dbd.H, halogen, CF.sub.3 or alkyl.

Logemann et al. Chem. Ab., 53, 18052 g (1959), disclose a number of sulfonamides, including uracil derivatives and those having the formula: ##STR4## wherein R is butyl, phenyl or and R.sub.1 is hydrogen or methyl. When tested for hypoglycemic effect in rats (oral doses of 25 mg/100 g), the compounds in which R is butyl and phenyl were most potent. The others were of low potency or inactive.

Wojciechowski, J. Acta. Polon. Pharm. 19, p. 121-5 (1962) [Chem Ab., 59 1633 e] describes the synthesis of N-[(2,6-dimethoxypyrimidin-4-yl)aminocarbonyl]-4methylbenzenesulfonamide: ##STR5## Based upon similarity to a known compound, the author predicted hypoglycemic activity for the foregoing compound.

Netherlands Pat. No. 121,788, published Sept. 15, 1966, teaches the preparation of compounds of Formula (i), and their use as general or selective herbicides, ##STR6## wherein

R.sub.1 and R.sub.2 may independently be alkyl of 1-4 carbon atoms; and

R.sub.3 and R.sub.4 may independently be hydrogen, chlorine or alkyl of 1-4 carbon atoms.

Compounds of Formula (ii), and their use as antidiabetic agents, are reported in J. Drug. Res. 6, 123 (1974), ##STR7## wherein R is pyridyl.

The presence of undesired vegetation causes substantial damage to useful crops, especially agricultural products that satisfy man's basic food needs, such as soybeans, barley, wheat, and the like. The current population explosion and concomitant world food shortage demand improvements in the efficiency of producing these crops. Prevention or minimizing the loss of a portion of such valuable crops by killing, or inhibiting the growth of undesired vegetation is one way of improving this efficiency.

A wide variety of materials useful for killing, or inhibiting (controlling) the growth of undesired vegetation is available; such materials are commonly referred to as herbicides. The need exists, however, for still more effective herbicides that destroy or retard weeds without causing significant damage to useful crops.

SUMMARY OF THE INVENTION

This invention relates to novel compounds of Formulas I, II, and III and their agriculturally suitable salts, suitable agricultural compositions containing them, and methods of using them as selective, as well as general herbicides having both pre-emergence and post-emergence activity. Some of the compounds are especially useful for controlling weeds in crops such as soybeans: ##STR8## wherein

W' is O or S;

A' is H, Cl, Br, C.sub.1 -C.sub.4 alkyl, OCH.sub.3, NO.sub.2 or CF.sub.3 ; ##STR9## where

R.sup.III is H, C.sub.1 -C.sub.4 alkyl or C.sub.3 C.sub.4 alkenyl; when Q is O or S then

R.sup.I is C.sub.1 -C.sub.6 alkyl; C.sub.3 C.sub.6 alkenyl; C.sub.3 -C.sub.6 alkynyl; C.sub.2 -C.sub.6 alkyl substituted with 1-3Cl, F or Br, or one of CN or OCH.sub.3 ; C.sub.3 -C.sub.6 alkenyl substituted with 1-3 Cl; C.sub.3 -C.sub.6 alkynyl substituted with Cl; C.sub.5 -C.sub.6 cycloalkyl; cyclohexenyl; cyclohexyl substituted with 1-3 CH.sub.3 ; C.sub.4 -C.sub.7 cycloalkylalkyl or ##STR10## where R.sub.7 and R.sub.8 are independently H, Cl, CH.sub.3 or OCH.sub.3 ;

n is 0 or 1; and

R.sub.9 is H or CH.sub.3 ;

when Q is O then R.sup.I is ##STR11## CH.sub.2 OR.sub.6 '; where R.sub.6 ' is C.sub.1 -C.sub.4 alkyl; provided R.sup.I has a total of .ltoreq.13 carbon atoms; when Q is ##STR12## then

R.sup.I is H; C.sub.1 -C.sub.6 alkyl; -CH.sub.2 CH.sub.2 OR.sub.10 ; -CH.sub.2 CH.sub.2 CH.sub.2 OR.sub.10 ; where R.sub.10 is CH.sub.3, CH.sub.3 CH.sub.2, CH(CH.sub.3).sub.2, or phenyl; C.sub.3 -C.sub.6 alkenyl; C.sub.3 -C.sub.6 cycloalkyl; C.sub.5 -C.sub.6 cycloalkenyl; C.sub.6 cycloalkyl substituted with any one of 1-2 OCH.sub.3, 1-3 CH.sub.3, -CH.sub.2 CH.sub.3 or CH.sub.3 ; C.sub.4 -C.sub.7 cycloalkylalkyl; --CH.sub.2 CN; --CH.sub.2 CH.sub.2 CN; ##STR13## where

R' is H, C.sub.1 -C.sub.4 alkyl, OCH.sub.3, F, Cl, Br, CN, NO.sub.2 or CF.sub.3 ;

R" is H, CH.sub.3, Cl, F or Br;

R.sub.7, R.sub.8 and R.sub.9 are as previously defined; R.sub.6 is H, C.sub.1 -C.sub.3 alkyl; CH.sub.2 CN; CH.sub.2 CH.sub.2 --CN or --CH.sub.2 --CH.dbd.CH.sub.2 and R.sub.6 and R.sup.I may be taken together to form--(CH.sub.2).sub.4 --, --(CH.sub.2).sub.5 --or --CH.sub.2 CH.sub.2 O--CH.sub.2 CH.sub.2 --; with the proviso that when R.sub.6 is CH.sub.2 CH.sub.2 CN or CH.sub.2 CN, then R.sup.I is CH.sub.2 CH.sub.2 CN or CH.sub.2 CN; and R.sup.I and R.sub.6 have a total carbon atom cound of .ltoreq.13; and when R.sup.I is OCH.sub.3 or OCH.sub.2 CH.sub.3 then R.sub.6 is CH.sub.3 or H; when A is ##STR14## then

R.sup.II is H, C.sub.1 -C.sub.6 alkyl; C.sub.3 -C.sub.6 alkenyl; phenyl; benzyl; benzyl or phenyl substituted with 1--2 Cl, 1--2 OCH.sub.3, 1--2 CH.sub.3 ; C.sub.5 -C.sub.6 cycloalkyl; C.sub.4 --C.sub.7 cycloalkylalkyl with the proviso that when T is .dbd.N--OR.sup.III, then R.sup.II must be C.sub.1 --C.sub.6 alkyl or Ch.sub.3 --C.sub.6 alkenyl; B is ##STR15## where

R.sub.4 is H or CH.sub.3 ; W is O or S;

R.sub.5 is H, or CH.sub.3 ; with the proviso that either R.sub.4 or R.sub.5 must be H;

R.sup.IV is C.sub.1 --C.sub.6 alkyl or C.sub.3 --C.sub.4 alkenyl; ##STR16## where Z is N, CH or C-F;

X.dbd.H, Cl, --CH.sub.3, --OCH.sub.3 or --OCH.sub.2 CH.sub.3 ;

Y.dbd.H; Cl; c.sub.1 --C.sub.4 alkyl substituted with ##STR17## C.sub.3 --C.sub.4 akenyl; --O--(CH.sub.2).sub.n' O-(C.sub.1 --C.sub.3 alkyl) where n' is 2 or 3; ##STR18## --N(C.sub.1 --C.sub.4 alkyl).sub.2 or C.sub.1 --C.sub.6 alkoxy; SCN; --N.sub.3 ; NR.sub.11 R.sub.12 where R.sub.11 is H or CH.sub.3 and R.sub.12 is H, --OCH.sub.3, C.sub.1 --C.sub.4 alkyl, C.sub.3 --C.sub.6 cycloalkyl, C.sub.3 --C.sub.4 akenyl, C.sub.2 --C.sub.3 alkyl substituted with OCH.sub.3 or OC.sub.2 H.sub.5, C.sub.1 --C.sub.2 alkyl substituted with --CN, CO.sub.2 H, CO.sub.2 CH.sub.3 or CO.sub.2 C.sub.2 H.sub.5, and R.sub.11 and R.sub.12 can be taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 --or CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 --; --O--R.sub.9 where R.sub.9 is C.sub.1 --C.sub.4 alkyl, C.sub.2 --C.sub.4 alkyl substituted with 1--3 atoms of F, Cl or Br, C.sub.1 --C.sub.2 alkyl substituted with cyano, C.sub.3 -- C.sub.4 alkenyl, --CH.sub.2 C.tbd.CR.sub.13, ##STR19## R.sub.13 is H, CH.sub.3 or CH.sub.2 Cl; SR.sub.14 ; where R.sub.14 is C.sub.1 --C.sub.4 alkyl, allyl, propargyl or C.sub.1 --C.sub.2 alkyl substituted with CN; with the proviso that when X and Y are both H, then

R.sup.I and R.sup.II are less than 5 carbons;

X.sub.1 .dbd.H, Cl, OCH.sub.3, OCH.sub.2 CH.sub.3 or CH.sub.3 ;

Y.sub.1 .dbd.H, OCH.sub.3 or CH.sub.3 ; and

X.sub.II .dbd.O or CH.sub.2 and further provided that when A contains greater than 5 carbon atoms, then Y must contain .ltoreq.4 carbon atoms,

and their agriculturally suitable salts.

Preferred Compounds

Preferred for reasons of higher activity and/or lower cost and/or greater ease of synthesis are compounds:

(1) Of the Generic scope in which B is ##STR20##

More Preferred and in increasing order for reasons of higher activity and/or even lower cost and/or even greater ease of synthesis are compounds:

(2) Preferred (1) in which W' is sulfur;

(2a) More Preferred (2) in which T is oxygen;

(3) More Preferred (2a) in which R.sub.1 is ##STR21##

(4) More Preferred (3) where Q is O or S and R.sub.I is C.sub.1 --C.sub.4 alkyl; C.sub.3 --C.sub.4 alkenyl; c.sub.3 --C.sub.4 alkynyl; C.sub.2 --C.sub.3 alkyl substituted with CN, OCH.sub.3 or 1--3 F, Cl or Br; C.sub.3 --C.sub.4 alkenyl substituted with 1--3 Cl; C.sub.3 --C.sub.4 alkynyl substituted with Cl;

(5) More Preferred (3) in which O is oxygen and R.sup.I is CH.sub.2 CH.sub.2 OR.sub.15 ; CH.sub.2 Ch.sub.2 CH.sub.2 OR.sub.15 ; ##STR22## where R.sub.6.sup.' is CH.sub.3 or CH.sub.3 CH.sub.2 ; ##STR23##

(6) More Preferred (3) in which O is ##STR24## and R.sup.I is H, C.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.sub.2 OR.sub.10, CH.sub.2 CH.sub.2 CH.sub.2 OR.sub.10 where R.sub.10 is CH.sub.3 or CH.sub.3 CH.sub.2 ; C.sub.3 -C.sub.4 alkenyl; CH.sub.2 CN; CH.sub.2 CH.sub.2 CN; OCH.sub.3 or OCH.sub.2 CH.sub.3 ; R.sup.6 is H, C.sub.1 -C.sub.2 alkyl, CH.sub.2 CN or CH.sub.2 CH.sub.2 CN and R.sub.6 and R.sup.I can be taken together to form (CH.sub.2).sub.4.

(7) More Preferred (3) in which R.sup.II is H or C.sub.1 -C.sub.3 alkyl;

(8) More Preferred (4), (5), (6), and (7) in which

Z is CH or N;

X is CH.sub.3 or CH.sub.3 O; and

Y is C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkyl substituted with OCH.sub.3 ; OCH.sub.2 CH.sub.3, CN or 1-3 atoms of F, Cl or Br; ##STR25## where L is NH.sub.2, OH, ##STR26## N(CH.sub.3).sub.2, NHCH.sub.3, C.sub.1 -C.sub.2 alkoxy; SCN; N.sub.3 ; NR.sub.11 R.sub.12 where R.sub.11 is H or CH.sub.3 ; R.sub.12 is H, CH.sub.3, CH.sub.3 CH.sub.2, OCH.sub.3 ; OR.sub.9 where R.sub.9 is CH.sub.3, CH.sub.3 CH.sub.2 ; CH.sub.2 CH.dbd.CH.sub.2 or CH.sub.2 C.tbd.CH; R.sub.9 is also C.sub.2 alkyl substituted with 1-3 F, Cl or Br; CH.sub.3 S;

(9) More Preferred (3) in which A' is H, Cl or Br;

(10) More Preferred (9) in which Q is O or S and R.sup.I is C.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.dbd.CH.sub.2 or CH.sub.2 CH.sub.2 Cl;

(11) More Preferred (9) in which Q is O and R.sup.I is CH.sub.2 CH.sub.2 OCH.sub.3, ##STR27##

(12) More Preferred (9) in which Q is ##STR28## and R.sup.I is H, C.sub.1 -C.sub.3 alkyl, OCH.sub.3 or OCH.sub.2 CH.sub.3 and R.sub.6 is H or C.sub.1 -C.sub.2 alkyl;

(13) More Preferred (9) in which R.sup.II is H or CH.sub.3 ;

(14) More Preferred (10), (11), (12) and (13) in which A' is H; Y is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, OCH.sub.2 CF.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 C.tbd.CH;

(15) More Preferred (8) in which A is ##STR29## and Q is oxygen or sulfur and R.sup.I is Ch.sub.3 or CH.sub.2 CH.sub.3 ; Q is ##STR30## and R.sup.I is H, CH.sub.3 or OCH.sub.3 and R.sub.6 is CH.sub.3 ; R.sub.1 is ##STR31## and Y is CH.sub.3 or OCH.sub.3 ;

(16) More Preferred (15) of Formula I;

(17) More Preferred (15) of Formula II;

(18) More Preferred (15) of Formula III.

Equally More Preferred in increasing order and for reasons of higher activity and/or even lower cost and/or even greater ease of synthesis are:

(19) Compounds of Preferred (1) in which W' is oxygen;

(20) Compounds of More Preferred (19) in which T is oxygen;

(21) More Preferred (20) in which R.sub.1 is ##STR32##

(22) More Preferred (21) where Q is O or S and R.sub.1 is C.sub.1 -C.sub.4 alkyl; C.sub.3 -C.sub.4 alkenyl; C.sub.3 -C.sub.4 alkynyl; C.sub.2 -C.sub.3 alkyl substituted with CN, OCH.sub.3 or 1-3 F, Cl or Br; C.sub.3 -C.sub.4 alkenyl substituted with 1-3 Cl; C.sub.3 -C.sub.4 alkynyl substituted with Cl;

(23) More Preferred (21) in which Q is oxygen and R.sup.I is Ch.sub.2 CH.sub.2 OR.sub.15 ; CH.sub.2 CH.sub.2 CH.sub.2 OR.sub.15 ; ##STR33## where R.sub.15 is CH.sub.2 CH.sub.3 ; CH.sub.2 CN; CH.sub.2 OR.sub.6.sup.' where R.sub.6 .sup.' is CH.sub.3 or CH.sub.3 CH.sub.2 ; ##STR34##

(24) More Preferred (21) in which Q is ##STR35## and R.sup.I is H, C.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.sub.2 OR.sub.10, CH.sub.2 CH.sub.2 CH.sub.2 OR.sub.10 where R.sub.10 is CH.sub.3 or CH.sub.3 CH.sub.2 ; C.sub.3 -C.sub.4 alkenyl; CH.sub.2 CN; CH.sub.2 CH.sub.2 CN; OCH.sub.3 or OCH.sub.2 CH.sub.3 ; R.sup.6 is H, C.sub.1 -C.sub.2 alkyl, CH.sub.2 CN or CH.sub.2 CH.sub.2 CN and R.sub.6 and R.sup.I can be taken together to form (CH.sub.2).sub.4.

(25) More Preferred (21) in which R.sup.II is H or C.sub.1 -C.sub.3 alkyl;

(26) More Preferred (22), (23), (24) and (25) in which Z is CH or N; X is CH.sub.3 or CH.sub.3 O; and Y is C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkyl substituted with OCH.sub.3 ; OCH.sub.2 CH.sub.3, CN or 1-3 atoms of F, Cl or Br; ##STR36## where L is NH.sub.2, OH, ##STR37## N(CH.sub.3).sub.2, NHCH.sub.3, C.sub.1 -C.sub.2 alkoxy; SCN; N.sub.3 ; NR.sub.11 R.sub.12 where R.sub.11 is H or CH.sub.3 ; R.sub.12 is H, CH.sub.3, CH.sub.3 CH.sub.2, OCH.sub.3 ; OR.sub.9 wherein R.sub.9 is CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.2 CH.dbd.CH.sub.2 or CH.sub.2 C.tbd.CH; R.sub.9 is also C.sub.2 alkyl substituted with 1-3 F, Cl or Br; CH.sub.3 S;

(27) Preferred (21) in which A' is H, Cl or Br;

(28) More Preferred (27) in which Q is O or S and R.sup.I is C.sub.1 -C.sub.4 alkyl, CH.sub.2 CH.dbd.CH.sub.2 or Ch.sub.2 CH.sub.2 Cl;

(29) More Preferred (27) in which Q is O and R.sup.I is CH.sub.2 CH.sub.2 OCH.sub.3, ##STR38##

(30) More Preferred (27) in which Q is ##STR39## and R.sup.I is H, C.sub.1 -C.sub.3 alkyl, OCH.sub.3 or OCH.sub.2 CH.sub.3 and R.sub.6 is H or C.sub.1 -C.sub.2 alkyl;

(31) More Preferred (27) in which R.sup.II is H or CH.sub.3 ;

(32) More Preferred (28), (29), (30) and (31) in which A' is H; Y is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, OCH.sub.2 CF.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 CH.tbd.CH;

(33) More Preferred (27) in which A is ##STR40## and Q is oxygen or sulfur and R.sup.I is CH.sub.3 or CH.sub.2 CH.sub.3 ; Q is ##STR41## and R.sup.I is H, CH.sub.3 or OCH.sub.3 and R.sub.6 is CH.sub.3 ; R.sub.1 is ##STR42## and Y is CH.sub.3 or OCH.sub.3 ;

(34) More Preferred (33) of Formula I;

(35) More Preferred (33) of Formula II;

(36) More Preferred (33) of Formula III.

Specifically Preferred for reasons of highest activity and/or lowest cost and/or greatest ease of synthesis are:

methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thiophene carboxylate

methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thiophenec arboxylate

methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thio phenecarboxylate

methyl 3-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thio phenecarboxylate

methyl 3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thiop henecarboxylate

methyl 3-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-aminocarbonyl]aminosulfonyl]-2 -thiophenecarboxylate

methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-furancarbo xylate

methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-furancarbo xylate

methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-fura ncarboxylate

methyl 3-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-2-fura ncarboxylate

methyl 3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-2-furan carboxylate

methyl 3-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-aminocarbonyl]aminosulfonyl]-2 -furancarboxylate

methyl 2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-3-thiophene carboxylate

methyl 2-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-3-thiophenec arboxylate

methyl 2-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-3-thio phenecarboxylate

methyl 2-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-3-thio phenecarboxylate

methyl 2-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]-aminosulfonyl]-3-thiop henecarboxylate

methyl 2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-aminocarbonyl]aminosulfonyl]-3 -thiophenecarboxylate

methyl 2-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-3-furancarb oxylate

methyl 2-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-3-furancarbo xylate

methyl 2-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-3-furan carboxylate

methyl 2-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-furan carboxylate

methyl 2-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-furanc arboxylate

methyl 2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3- furancarboxylate

N-[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]-2-(1-pyrrolidinylcarbon yl)-3-thiophenesulfonamide

1-methylethyl 3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thiophene carboxylate

2-propenyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-aminocarbonyl]aminosulfonyl]-2-thio phenecarboxylate

1-methylethyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-aminocarbonyl]aminosulfonyl]-2-thio phenecarboxylate.

Novel Intermediates

Also novel and useful for the preparation of compounds of Formulas I, II and III are compounds of Formulas I', II' and III'. ##STR43## wherein

R.sup.I is H or M;

M is a cation of an alkalii metal or of a tertiary amine of up to 12 carbon atoms;

A', W', B, are as previously defined.

Preferred and in increasing order for reasons of lower cost and/or greater ease of synthesis and/or higher activity of derived compounds are those intermediate

(1) Compounds of formulas I', II' and III' in which W' is sulfur, B is SO.sub.2 NHCONHR.sub.1, A' is H, Cl or Br and R.sub.1 is ##STR44##

(2) Compounds of Preferred (1) in which X is CH.sub.3 or OCH.sub.3 ; Y is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, OCH.sub.2 CF.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 --C.tbd.C-H; Z is CH or N;

(3) Compounds of Preferred 2) in which Y is CH.sub.3 or OCH.sub.3 ; ##STR45## A' is H;

(4) Compounds of Preferred (3) of Formula I';

(5) Conmpounds of Preferred (4) of Formula II';

(6) Compounds of Preferred (5) of Formula III';

Equally Preferred in increasing order, for reasons of lower cost and/or greater ease of synthesis and/or higher activity of derived compound are those intermediate:

(7) Compounds of formulas I', II' and III' in which W' is oxygen; B is SO.sub.2 NHCONHR.sub.1, A' is H, Cl or Br, and ##STR46##

(8) Compounds of Preferred (7) in which X is CH.sub.3 or OCH.sub.3 ; Y is CH.sub.3, OCH.sub.3, OCH.sub.2 CH.sub.3, OCH.sub.2 CF.sub.3, OCH.sub.2 CH.dbd.CH.sub.2 or OCH.sub.2 C.tbd.C-H; and Z is CH or N;

(9) Compounds of Preferred (8) in which Y is CH.sub.3 or OCH.sub.3 ; ##STR47##

A' is H;

(10) Compounds of Preferred (9) of Formula I',

(11) Compounds of Preferred (9) of Formula II';

(12) Compounds of Preferred (9) of Formula III';

Specifically Preferred for reasons of lowest cost and/or greatest ease of synthesis and/or highest activity or desired compounds are:

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiopheneca rboxylic acid

3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecar boxylic acid

3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thioph enecarboxylic acid

3-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-thioph enecarboxylic acid

3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophe necarboxylic acid

3-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-t hiophenecarboxylic acid

3-[[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-furancarbox ylic acid

3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-furancarboxy lic acid

3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-furanc arboxylic acid

3-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-furanc arboxylic acid

3-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-furanca rboxylic acid

3-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-2-f urancarboxylic acid

2-[[(4,6-dimethoxypyrimidin-2yl)aminocarbonyl]aminosulfonyl]-3-thiophenecar boxylic acid

2-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-3-thiophenecar boxylic acid

2-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-3-thioph enecarboxylic acid

2-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-thioph enecarboxylic acid 2-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-thioph enecarboxylic acid

2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-t hiophenecarboxylic acid

2-[[(4,6-dimethoxypyrimidin-2yl)aminocarbonyl]aminosulfonyl]-3-furancarboxy lic acid

2-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-3-furancarboxy lic acid

2-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-3-furanc arboxylic acid

2-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-furanc arboxylic acid

2-[[(4,6-dimethyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-furanca rboxylic acid

2-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]aminosulfonyl]-3-f urancarboxylic acid

Also novel and useful for the preparation of compounds of Formulas I, II and III are compounds of Formulas I", II" and III" ##STR48## wherein

W is oxygen or sulfur;

W' is oxygen or sulfur;

A' is H, Cl, Br, C.sub.1 -C.sub.4 alkyl, OCH.sub.3, NO.sub.2 or CF.sub.3 ;

R.sup.I is C.sub.1 -C.sub.6 alkyl; C.sub.3 -C.sub.6 alkenyl; C.sub.3 -C.sub.6 alkynyl; C.sub.2 -C.sub.6 alkyl substituted with Cl, CN or OCH.sub.3 ; C.sub.3 -C.sub.6 alkenyl substituted with 1-3 Cl; C.sub.3 -C.sub.6 alkynyl substituted with Cl; C.sub.5 -C.sub.6 cycloalkyl; cyclohexenyl; cyclohexyl substituted with 1-3 CH.sub.3 ; C.sub.4 -C.sub.7 cycloalkylalkyl or ##STR49## where R.sub.7 and R.sub.8 are independently H, Cl, CH.sub.3 or OCH.sub.3 ;

n is 0 or 1; and

R.sub.9 is ##STR50## where R.sub.15 is ##STR51## where R.sub.16 is CH.sub.3, C.sub.2 H.sub.5, CH(CH.sub.3).sub.2, phenyl, CH.sub.2 CH.sub.2 Cl, CH.sub.2 CCl.sub.3, and n' is 2 or 3; ##STR52## where R.sub.6 'is C.sub.1 -C.sub.4 alkyl; provided R.sup.I has a total of .sub..ltoreq. 13 carbon atoms.

Preferred in increasing order for reasons of lower cost and/or greater ease of synthesis and/or higher activity of desired compounds are those intermediate:

(1) Compounds of formulas I", II" and III" in which W' is sulfur; W is oxygen; A' is H, Cl or Br; and R.sup.I is C.sub.1 -C.sub.4 alkyl; ##STR53##

(2) Compounds of Preferred (1) in which R.sup.I is CH.sub.3 or CH.sub.2 CH.sub.3 ; A.sup.I is H;

(3) Compounds of Preferred (2) of Formula I";

(4) Compounds of Preferred (2) of Formula II";

(5) Compounds of Preferred (2) of Formula III".

Equally Preferred in increasing order for reasons of lower cost and/or greater ease of synthesis and/or higher activity of derived compounds are those intermediate:

(6) Compounds of formulas I", II", and III" in which W' is oxygen; W is oxygen; A' is H, Cl or Br;

(7) Compounds of Preferred (6) in which R.sup.I is CH.sub.3 or CH.sub.2 CH.sub.3 ; A.sup.I is H;

(8) Compounds of Preferred (7) of Formula I".

(9) Compounds of Preferred (7) of Formula II".

(10) Compounds of Preferred (7) of Formula III".

Specifically Preferred for reasons of lowest cost and/or greatest ease of synthesis and/or highest activity of desired compounds are:

methyl 3-(isocyanatosulfonyl)-2-thiophenecarboxylate

methyl 2-(isocyanatosulfonyl)-3-thiophenecarboxylate

methyl 4-(isocyanatosulfonyl)-3-thiophenecarboxylate

methyl 3-(isocyanatosulfonyl)-2-furancarboxylate

methyl 2-(isocyanatosulfonyl)-3-furancarboxylate

methyl 4-(isocyanatosulfonyl)-3-furancarboxylate

Synthesis

Many of the compounds of Formulas I-III are prepared as shown in Equation 3 by the reaction of an appropriately substituted alkoxycarbonylthiophene or furan sulfonylisocyanate or sulfonylisothiocyanate with an appropriate aminopyrimidine or aminotriazine. These compounds of Formulas I-III can be converted to other compounds of Formulas I-III as will be shown in subsequent equations.

The novel sulfonylisocyanates are important intermediates for the preparation of the compounds of this invention. Their synthesis is described in Equations 1 and 2. ##STR54##

A mixture of the appropriate sulfonamide, e.g. an 2-alkoxycarbonyl-3-thiophene sulfonamide IV such as the methyl ester, which is known in the art, an alkyl isocyanate such as butyl isocyanate and a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO) in xylene or other inert solvent of sufficiently high boiling point (e.g.>135.degree.) is heated to approximately 130.degree.-150.degree. C. Phosgene is added to the mixture until an excess of phosgene is present as indicated by a drop in the boiling point. After the mixture is cooled and filtered to remove a small amount of insoluble by-products, the solvent and alkyl isocyanate are distilled off in-vacuo leaving a residue which is the crude sulfonyl isocyanate V. In Equation 1,

A', W' and CO.sub.2 R.sup.I are as defined previously for structures I", II" and III".

The novel sulfonylisothiocyanate intermediates of Formula Va, prepared according to Equations 2 and 2', are useful for the preparation of compounds of Formulas I-III where W=S. ##STR55##

The alkoxycarbonyl substituted sulfonamide is dissolved in dimethylformamide (DMF) with an equivalent amount of carbon disulfide and two equivalents of potassium hydroxide are added portionwise at room temperature. The mixture is stirred for 1-8 hours and diluted with ethylacetate, ethyl ether or similar aprotic solvent to cause the dipotassium salt of the dithiocarbamic acid to precipitate. The salt is isolated, dried and suspended in an inert solvent such as xylene, benzene, carbon tetrachloride or methylene chloride. Phosgene is added to the stirred suspension at below room temperature and the mixture stirred for 1-3 hours. In place of phosgene, a chloroformic ester (e.g. methyl chloroformate), phosphorous pentachloride, sulfuryl chloride or thionyl chloride can be used.

The sulfonylisothiocyanate which is formed is usually soluble in the solvent and is isolated by filtering off the insoluble potassium chloride and concentrating the filtrate. These isothiocyanates tend to be unstable and dimerize readily, (Equation 2') however, the dimers can be used

Alternate routes to prepare sulfonylisothiocyanates are described by M. O. Lozinskii et al. in Organic Compounds: Reactions and Methods, Ed. by B. A. Kazanskii et al., Vol 22, p 188-197, Plenum Press, 1973 (Engl. Trans.) ##STR56## in the same manner as the parent isothiocyanates for the purposes of this invention.

The synthetic method chosen for the preparation of compounds of Formulas I-III depends largely on the substituents QR.sup.I and R.sub.4. As shown in Equation 3, compounds of Formulas I-III wherein R.sup.I or A' are as defined for Equation 1, are conveniently prepared by reacting an appropriately substituted carbonyl thiophene or furan sulfonyl isocyanate or isothiocyanate of Formula V with an appropriately substituted aminopyrimidine or aminotriazine of Formula VI: ##STR57##

The reaction of Equation 3 is best carried out in inert aprotic organic solvents such as methylene chloride, tetrahydrofuran or acetonitrile, at ambient pressure and temperature. The mode of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or isothiocyanate to a stirred suspension of amine VI. Since such isocyanates and isothiocyanates are liquids, low melting solids or are readily soluble in solvents such as those listed above, their addition can be easily controlled.

The reaction is generally exothermic. In some cases, the desired product is soluble in the warm reaction medium and on cooling crystallizes in pure form. Other products which are soluble in the reaction medium are isolated by evaporation of the solvent, trituration of the solid residue with solvents such as 1-chlorobutane or ethyl ether, and filtration.

As shown in Equation 4, compounds of Formulas I-III, wherein W is S, A and A' are as previously defined and R.sub.5 is H, are altervatively prepared by the reaction of an appropriately substituted thiophene or furan sulfonamide with the appropriate triazine or pyrimidine isothiocyanate of Formula VIa. ##STR58##

The reaction of Equation 4 is best carried out by dissolving or suspending the sulfonamide and isothiocyanate in a polar solvent such as acetone, acetonitrile, ethyl acetate or methylethylketone, adding an equivalent of a base such as potassium carbonate and stirring the mixture at a temperature from ambient up to the reflux temperature for one to twenty-four hours. In some cases, the product precipitates from the reaction mixture and can be removed by filtration. The product is stirred in dilute mineral acid, filtered and washed with cold water. If the product does not precipitate from the reaction mixture, it can be isolated by evaporation of the solvent, trituration of the residue with dilute mineral acid and filtering off the insoluble product.

The heterocyclic isothiocyanates which are used in the procedure of Equation 4 are prepared, for example, according to the method of Japan Patent Application Pub: Kokai 51-143686, June 5, 1976, or that of W. Abraham and G. Barnikow, Tetrahedron 29, 691-7 (1973).

As shown in Equation 5, compounds of Formulas I-III, wherein A, A', R.sub.1, W', and and R.sub.5 are as defined previously, and W is O, can be prepared by methylation of salts VII wherein M is an alkali metal cation such as sodium (derived from compounds of Formulas I-III wherein R.sub.4 is hydrogen): ##STR59## D being an incipient anion and n being an integer corresponding to the valence of D.

The reaction of Equation 5 is best carried out in aprotic organic solvents such as tetrahydrofuran, dimethylformamide, or dimethylacetamide, at ambient pressure and temperature. Methylating agents VIII such as dimethyl sulfate or methyl iodide, can be employed. The desired product can be isolated by pouring the reaction mixture into water and filtering off the precipitated solid.

As shown in Equation 6, compounds of Formulas I-III wherein A, A', R.sub.1, W', and R.sub.5 are as defined for Equation 5, and W is O or S, can also be prepared by the reaction of an appropriately substituted sulfonyl-N-methylcarbamyl chloride or sulfonyl-N-methylthiocarbamyl chloride of Formula IX with an appropriate aminopyrimidine or aminotriazine of Formula VI; ##STR60##

The preparation of ureas and thioureas, like those of Formula Ic, from amines and carbamyl chlorides and thiocarbamyl chlorides is well known to the art. The reaction can best be carried out by adding equivalent amounts of chloride IX and amine VI to an inert organic solvent, such as tetrahydrofuran, xylene, or methylene chloride, in the presence of an acid acceptor, such as triethylamine, pyridine, or sodium carbonate employing temperatures from 20.degree.-130.degree.. Soluble products can be isolated by filtering off the precipitated salts and concentration of the filtrate. Insoluble products can be filtered off and washed free of salts with water.

The chlorides of Formula IX can be prepared by phosgenation or thiophosgenation of N-methylsulfonamide salts. The sulfonamide salt is added to an excess of phosgene or thiophosgene in an inert organic solvent, such as tetrahydrofuran, toluene, or xylene, whereupon, after removal of the excess phosgene, the chloride IX can be isolated or reacted in situ with the amine VI.

The esters of Formulas I-III hydrolyze to the parent acid as shown in Equation 7. Alkali metal base catalyzed hydrolysis in aqueous methanol produces the alkali metal carboxylate from which the carboxylic acid is obtained by treatment with mineral acids such as HCl: ##STR61##

The reaction of Equation 7 is best carried out in a solution containing the compound being hydrolyzed, 2 to 10 parts of methanol, 10-50 parts of water and 2-10 equivalents of a base such as sodium or potassium hydroxide maintaining the temperature at 30-90.degree. C. for 3-24 hours. the reaction yields the soluble alkali metal salt of the carboxylic acid, which is suitable for the purposes of this invention. Conversion of these salts to the acid form is easily carried out by addition to the reaction medium of strong mineral acids, such as hydrochloric or sulfuric acid, causing the desired carboxylic acids to precipitate from solution.

The acids of Formula Ie prepared as in Equation 7 wherein W is O can be converted to compounds of this invention where R.sup.I is a higher alkyl or substituted hydrocarbyl group, as already disclosed herein, by the reaction of salts of the parent acid with R.sup.I -halogen as shown in Equation 8. ##STR62##

The reaction of Equation 8 is of use where the intermediate compound R.sup.I -halogen contains a readily replaceable halogen as is the case for substituted or unsubstituted allylic or benzylic halides, .alpha.-halonitriles, or .alpha.-halocarbonyl compounds.

The procedure of Equation 8 is best carried out in inert polar solvents such as tetrahydrofuran, acetonitrile or acetone by combining the appropriately substituted carboxylic acid and base such as triethylamine or 1,4diaza[2,2,2]bicyclooctane adding the appropriate halide and heating the mixture to reflux with stirring for 1 to 16 hours. The reaction mixture can be evaporated to dryness and the residue triturated with water, filtered and washed with water to separate the desired product from the water soluble salt.

The procedure of Equation 8 can also be used for the synthesis of compounds wherein R.sup.I -halogen of Equation 8 is of a less reactive species than described above. In these cases, the silver salt of the carboxylic acid is used rather than the amine salt. The silver salt which is precipitated by adding silver nitrate to an aqueous solution of the sodium salt of the acid of Formula Ie is combined with the appropriate R.sup.I -halide using the same solvents and conditions as shown above for the amine salt.

When Q is NR.sub.6, the compounds can be prepared from the esters of this invention where R.sup.I is c.sub.1 -C.sub.4 (preferably C.sub.1) by the reaction of the esters with dialkylaluminum-N-alkylamide derivatives according to Equation 9; R.sup.I, A', W', R.sub.1, R.sub.4, R.sub.5 and R.sub.6 being as previously defined. ##STR63##

The intermediate alkylaminoaluminum compounds prepared according to A. Basha, M. Lipton and S. W. Weinreb, Tetrahedron Letters 4171 (1977), are comingled with a suspension of the esters in toluene or similar inert solvent and the mixture is refluxed for one to six hours. The product can be isolated by evaporation of the solvent, addition of methylene chloride and aqueous hydrochloric acid to decompose the residual reaction mass and extracting the desired product into the methylene chloride. Evaporation of the methylene chloride yields the desired product in sufficiently pure form for the purpose of this invention.

Compounds of Formula X, wherein Q is ##STR64## A', W' and R.sub.4 are as previously defined in the general formula, which are useful as intermediates in Equation 4, are prepared as shown in Equation 10. ##STR65## The conditions described for Equation 8 are suitable for the conversion of the esters of Formula IVa to the carboxamides as shown in Equation 10.

The products of Equation 10 are especially useful for the preparation of compounds of Formulas I-III wherein Y has an ester substituent CO.sub.2 (C.sub.1 -C.sub.6), by the route described in Equation 4.

When Q is S, these compounds can be prepared from the esters of this invention wherein QR.sup.I is O(C.sub.1 -C.sub.4 alkyl) (preferably C.sub.1) by the reaction of the esters with the appropriate dialkylaluminum alkylthiolate according to Equation 11. ##STR66##

The intermediate aluminum thiolates can be prepared according to R. P. Hatch and S. W. Weinreb, Journal of Organic Chemistry, Vol. 42, 3960 (1977). The reaction of the thiolate with the ester of this invention is best carried out in a neutral solvent such as toluene or xylene at reflux for one to three hours. Best results are obtained when the aluminum thiolate compound is present in excess of the stoichiometric amount required.

Sulfonamides of Formula IVcf are also converted from carboxylic acid esters to the thiolesters as shown in Equation 12 according to the method of R. P. Hatch and S. W. Weinreb as described for Equation 11 wherein R.sup.I, A', W' and R.sub.4 are as previously defined. ##STR67## The conditions described for Equation 11 are suitable for the conversion of the sulfonamides of Formula IVc as shown in Equation 12.

The products obtained by the procedure of Equation 12 are especially useful for the preparation of compounds of formulas I-III where Y has a substituent (CO.sub.2 C.sub.1 -C.sub.6) by the route described for Equation 4 and Q=S.

An alternate route to prepare compounds where R.sup.I is bonded to Q (Q=O) at a secondary carbon involves the reaction of the appropriate dialkylaluminum alcoholate and an ester of this invention wherein R.sup.I is a lower primary alkyl group, preferably methyl, according to Equation 13. ##STR68##

The reaction is carried out in a neutral solvent such as toluene with a boiling point sufficiently high to bring about the desired reaction during reflux. The dialkylaluminum alcoholate being present in greter than an equivalent amount to the ester for best yields. After refluxing for 1-15 hours, the reaction mixture is decomposed with dilute hydrochloric acid and the product extracted into methylene chloride. Evaporation of the methylene chloride yields the desired compound sufficiently pure for the purposes of this invention. The product can be triturated with a solvent, e.g. 1-chlorobutane to remove impurities.

Ketones wherein A is ##STR69## and A', W', W, R.sub.1, R.sub.4 and R.sub.5 are as defined by the scope of this invention, are prepared according to Equation 14, from the carboxylic acids of Formula Ie whose preparation is described in Equation 7. ##STR70##

The reaction of an organolithium compound with a carboxylic acid to yield a ketone as in Equation 14 is described in the work of H. Gilman and P. R. Van Ess, JACS, 55, 1258 (1933); H. Gilman, W. Langham and F. W. Moore, ibid., 62 (1940); C. Tegner, Chem. Scand., 6, 782 (1952); J. F. Arens and D. A. Van Dorp, Rec. Trav., 65 338 (1946); 66, 759 (1948); C. H. Depuy, G. M. Dappen, K. L. Eilers and R. A. Klein, J. Org., 29, 2813 (1964).

An excess of the organolithium compound in a suitable solvent such as diethyl ether, hexane, pentane or benzene is added to a solution or slurry of XI in a similar solvent at temperatures between -100 and 0.degree. C. The mixture is allowed to warm to room temperture and stir for 30 minutes. Aqueous acid is then added and the ketosulfonamide extracted into a suitable solvent to free it from salts followed by evaporation of the solvent.

The synthesis of a wide variety of organolithium compounds by many different procedures is known in the art. A summary of methods with bibliography is contained in Organo-Metallic Compounds, G. E. Coates, John Wiley and Sons, 1960, p. 3-21.

Oximes of the ketones of Formula XI, for example, can be prepared from the appropriate hydroxylamine derivative, wherein R.sup.III is as previously defined, and the ketone of Formula XI according to Equation 15. ##STR71##

A procedure such as that described in Preparative Organic Chemistry by G. Hilgetag and A. Martini, Ed., John Wiley and Sons, p. 513 is suitable for the preparation of the oximes of this invention.

Compounds of Formulas I-III wherein B is ##STR72## and W is O, are prepared by the sequence of reactions shown in Equation 16. ##STR73##

The compounds of Formula XVII are prepared by adding an appropriate carbon tetrahalide to a solution of a compound of Formula XII and triphenyl phosphine in an inert aprotic solvent such as acetonitrile at about -10.degree. to 25.degree. and stirring at the designated temperature for 10 to 48 hours. The carbamimidoyl halides of Formula XVI thus formed may be isolated by passing the reaction solution through a silica gel column to remove the triphenyl phosphine oxide and removal of the solvent by evaporation under reduced pressure.

The compounds of Formula XVI can be converted to the corresponding compounds of Formula XVII by treating reaction mixture with a metal alkoxide, NaOR.sup.III, at -10.degree. to 25.degree. and stirring at ambient temperature for 2 to 24 hours. The crude products of Formula XVII are isolated by filtering off the precipitated metal halide and removing the solvent by evaporation under reduced pressure. Further purification may be accomplished by recrystallization or by column chromatography over silica gel.

It will be understood that the compounds of Formula XVI are not necessarily converted directly to the compounds of Formula XVII, but may first form the carbodiimides of Formula XVIII. ##STR74##

Many compounds, particularly compounds in which the heterocyclic moiety is pyrimidinyl, may be prepared by the sequence of reactions shown in Equation 17. ##STR75##

The compounds of Formula XIX are prepared according to the procedure or R. Gompper and W. Hagele in Chemische Berichte 99, 2885-2899 (1966).

The compounds of Formula XX are prepared from the compounds of Formula XIX with sulfuryl chloride in an inert organic solvent such as methylene chloride or chloroform at temperatures between -10.degree. and 80.degree.. They are isolated by removing the solvent under reduced pressure, and can be used without further purification.

The compounds of Formual XXI are prepared in the following manner: The lithium salt of the appropriate aminoheterocycle is prepared from the aminoheterocycle with n-butyl lithium in a solvent such as tetrahydrofuran. To this salt solution is added the compound of Formula XX in tetrahydrofuran at a temperature of about -10.degree. to 10.degree.. The reaction mixture is then stirred at about 0.degree.-10.degree. for 1/2-2 hours and at ambient temperature for 1/2-4 hours. The products of Formula XXI are isolated by filtering off the inorganic salts and removing the solvent under reduced pressure. Further purification can be done by recrystallization or by column chromatography on silica gel using a suitable eluent such as ethyl acetate.

As shown in Equation 18, the compounds of Formula XXIV, wherein ##STR76## and W=S can be prepared by reacting an appropriately substituted carbamimidothioic acid salt of Formula XXII with an alkylating agent of Formula XXIII. ##STR77## wherein D is a sulfate or halogen, such as Cl, Br, or I; M is an alkali or alkaline earth metal, and n is an integer corresponding to the valence of D.

The reaction is best carried out in inert aprotic organic solvents such as tetrahydrofuran or diethyl ether at temperatures between 25.degree. and 100.degree. C. and ambient pressure. The mode of addition is not critical; however, it is often convenient to add the alkylating agent in solution to a stirred suspension of the salt of Formula XXII. The product is isolated by evaporation of the solvent and can be purified by recrystallization from a solvent such as acetonitrile or ethanol.

The metal salts of Formula XXII can be prepared by treating the corresponding sulfonylthiourea with a solution of an alkali metal or alkaline earth metal salt having an anion sufficiently basic to the proton (e.g. hydroxide, alkoxide, caronate or hydride).

When Z is N, the preferred procedure for the preparation of compounds of Formula XXIV is that shown in Equation 19. ##STR78##

A compound of Formula XXV is treated with an alkali metal (M') salt of the appropriately substituted heterocyclic amine at temperatures of 0.degree. to 100.degree. C. in a solvent such as dimethylformamide, dimethylsulfoxide or an ethereal solvent, such as tetrahydrofuran.

Compounds of Formula XXV can be prepared according to the procedure of Chem. Ber. 99, 2885 (1966).

Compounds of Formulas I-III wherein Y of group R.sub.1 contains ##STR79## and L is OH can be prepared according to the procedure of Equation 20 wherein A', W', X, R.sub.4, W and R.sub.5 are as defined previously; and Q' is C.sub.1 -C.sub.4 alkyl ##STR80## where R.sub.11 is as previously defined. ##STR81##

The reaction of Equation 20 is best carried out by suspending the compound being hydrolyzed in 10 to 100 parts of water with enough of a base such as sodium hydroxide or potassium hydroxide to obtain a pH 10 to 14, ideally a pH of 12, heating until a clear solution is obtained and then adjusting the pH to 1-3, preferably 3. The product is thus caused to precipitate in some instances and can be removed by filtration or it can be extracted into a polar organic solvent such as methylene chloride and isolated by evaporation of the solvent.

Thiophene derivatives with sulfamoyl and alkoxycarbonyl substituents on adjacent carbon atoms are prepared by the methods taught by O. Hromatka and D. Binder, U.S. Pat. No. 4,028,373 and P. A. Rossy et al., U.S. Pat. No. 4,143,050. The analogous furan derivatives are prepared similarly or as taught in Belgian Pat. No. 871,772.

Alternate methods of preparation of thiophene and furan sulfonamides with alkoxycarbonyl substituents adjacent to the sulfonamide are preferable in certain circumstances. For example, if one of the .alpha.-carbons is not substituted, chlorosulfonation of a furan or thiophene may give the undesired substituted sulfonyl chloride or a mixture of isomers. Regiospecific introduction of substituents may be achieved in many cases via ring metalation reactions. The use of such reactions has been reviewed by H. Gschwend and H. Rodriguez in "Organic Reactions", Vol. 26 (John Wiley & Sons, Inc., New York, 1979). Using these methods, the 2-lithio-3-furancarboxylates or -thiophenecarboxylates may be generated from the corresponding acid and two equivalents of an alkyllithium in an inert, aprotic solvent such as an ether solvent. These intermediates are described in ##STR82## Tetrahedron Letters 5051 (1980) and references therein. Treatment of these organolithium species with sulfur dioxide afford the corresponding 2-sulfinate-3-carboxylate salts which are conveniently isolated by evaporation of the solvent. The lithium sulfinates are converted to the sulfonamides by reaction with an excess of chloramine in aqueous solution and isolated by acidification and extraction ##STR83## into an organic solvent. Esterification of the resulting acids under standard conditions (e.g., methanol, sulfuric acid catalyst, 25.degree.-65.degree. C. 1-24 h ) yield the appropriate alkoxycarbonyl sulfonamides.

Other isomeric furan and thiophene sulfonamides may be prepared through a sequence of these metalation reactions as shown below. The reaction of 3-bromofurans or -thiophenes with alkyllithium reagents at low temperatures (preferably below -40.degree.) in an aprotic, inert solvent afford the corresponding 3-lithiofurans and -thiophenes via halogen-metal exchange. These may be quenched with sulfur dioxide to yield the 3-sulfinic acid salts. They may be subsequently ##STR84## converted to sulfonyl chlorides with a chlorinating agent, conveniently with a reagent such as N-chlorosuccinimide (NCS) in a suitable solvent such as acetic acid, preferably at ambient temperature. The ##STR85## 3-t-butylsulfonamide is then prepared upon reaction of the sulfonyl chloride with excess t-butylamine. Reaction of the sulfonamide with ##STR86## two equivalents of an alkyllithium, as described above for the 3-carboxylic acids, yield specifically the 2-lithio intermediates which are quenched with carbon dioxide to afford the 2-carboxylic acid salts. Esterification of the carboxylic acid and removal of the t-butyl group may be accomplished in one reaction by heating the above products in an alcohol solvent with acid catalyst (e.g. methanol, sulfuric acid). ##STR87##

For 3,4-disubstituted furan and thiophene sulfonamides, a modification of the above sequence is appropriate. A 4-bromo-3-t-butylsulfamoylthiophene or furan intermediate may be prepared by the methods outlined above beginning with the 3,4-dibromo compound. Reaction of these sulfonamides with ##STR88## two equivalents of alkyllithium in preferably an ether solvent at low temperature (preferably less than -40.degree.) will afford the 3-lithio species via halogenmetal exchange. These may be subsequently quenched with carbon dioxide to yield the carboxylic acids which are then converted to the free to the free sulfonamide-esters as outlined above for the 2,3-disubstituted isomers.

Compounds of structure XXIX wherein A is an aldehyde group and A' does not equal -NO.sub.2 are prepared by the procedure of Equation 21. ##STR89##

Following the procedure of R. Kanazawa and T. Tokoroyama, Synthesis, 526 (1976), a solution of sodium bis-(2-methoxyethoxy)aluminum hydride in THF is reacted with one equivalent or morpholine. To this solution at -40.degree. C. is added a methyl ester of Formula XXVIII and the solution is allowed to warm to 25.degree. C. The product is isolated by addition of aqueous acid and extraction into ether or methylene chloride. Evaporation of the solvent and crystallization or column chromatography on silica gel affords the aldehyde XXX.

Aldehydes of Formula XXX may also be prepared from the esters by treatment with diisobutylaluminum hydride according to the procedures of E. Winterfeldt, Synthesis, 617 (1975).

Compounds of Formulas I, II and III may also be prepared by the reaction of the appropriately substituted thiophene or furan sulfonamides with the appropriate heterocyclic isocyanate using the methods described in co-pending applications U.S. Ser. No. 098,725 and U.S. Ser. No. 098,722, filed Nov. 30, 1979.

The synthesis of heterocyclic amines has been reviewed in "The Chemistry of Heterocyclic Compounds" a series published by Interscience Publ., New York and London. 2-Aminopyrimidines are described by D. J. Brown in The Pyrimidines, Vol. XVI of this series. The 2-amino-1,3,5-triazines are reviewed by K. R. Huffman and in The Triazines of this same series. The synthesis of triazines are also described by F. C. Schafer, U.S. Pat. No. 3,154,547 and by K. R. Huffman and F. C. Schaeffer, J. Org. Chem. 28, 1816-1821 (1963).

The preparation of the aminoheterocycles described by Formula XXX varies according to the definition of Y.sub.1 and X.sub.II. ##STR90##

Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc. 69, 3072 (1947) describes the preparation of 6,7-dihydro-4-methoxy-5H-cyclopentapyrimidin-2-amine by the following sequence of reactions. ##STR91##

Similarly, 6,7-dihydro-4-methyl-5H-cyclopentapyrimidin-2-amine can be prepared by the condensation of 2-acetylcyclopentanone with guanidine carbonate, but preferably under acidic conditions, removing the water formed. ##STR92##

Shrage and Hitchings, J. Org. Chem. 16, 1153 (1951) described the preparation of 5,6-dihydro-4-methylfuro [2,3-d]pyrimidin-2-amine by the following sequence of reactions ##STR93##

5,6-Dihydro-4-methoxyfuro [2,3-d]pyrimidin-2-amine can be prepared by the method of Braker et al., J. Am. Chem. Soc. 69, 3072 (1947), using 5,6-dihydro-4-hydroxyfuro [2,3-d]pyrimidin-2-amine [Svab, Budesinski and Vavrina, Collection Czech. Chem. Commun. 32, 1582 (1967)]. ##STR94##

Caldwell, Kornfeld and Donnell, J. Am. Chem. Soc. 63, 2188 (1941), describe the preparation of 6,7-dihydro-5H-cyclopentapyrimidin-2-amine by the following sequence of reactions. ##STR95##

Fissekis, Myles and Brown, J. Org. Chem. 29, 2670 (1964), describe the preparation of 2-amino-4-hydroxy-5-(2-hydroxyethyl) pyrimidine which can be converted to 5,6-dihydrofuro [2,3-d]pyrimidin-2-amine by dehydration. ##STR96##

Agriculturally suitable salts of compounds of Formulas I-III are also useful herbicides and can be prepared by a number of ways known to the art. For example, metal salts can be made by treating compounds of Formulas I-III with a solution of alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydride). Quaternary amine salts can be made by similar techniques.

Salts of compounds of Formulas I-III can also be prepared by exchange of one cation to another. Cationic exchange can be effected by direct treatment of an aqueous solution of a salt of a compound of Formulas I-III (e.g., alkali metal or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water, e.g., a copper salt, and can be separated by filtration.

Exchange may also be effected by passing an aqueous solution of a salt of a compound of Formulas I-III (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged. In this method, the cation of the resin is exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water soluble, e.g., a potassium, sodium or calcium salt.

Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formulas I-III with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The compounds of this invention and their preparation are further illustrated by the following examples wherein temperatures are given in degrees centrigrade.

The desired product is underscored at the top of each example.

EXAMPLE 1

2-Methoxycarbonyl-3-thiophenesulfonyl isocyanate

A mixture containing 22.1 g of methyl-3-sulfamoylthiophene-2-carboxylate, 9.9 g of n-butyl isocyanate, 0.3 g of 1,4-diaza[2,2,2]bicyclooctane and 150 ml of dry xylene was placed in a 4 neck round bottom flask equipped with a gas inlet tube, mechanical stirrer, thermometer and dry ice cooled reflux condenser. This mixture was heated to 135.degree. C. and phosgene was passed into the flask so that after several minutes, the reflux temperature dropped to 120.degree.. The phosgene addition was halted until the temperature rose to 130.degree. and then additional phosgene was added to cause the temperature to drop again to 120.degree.. The phosgene addition cycle was repeated until the reflux temperature of the reaction mixture remained at 120.degree. with no further phosgene addition.

Cooling the reaction mixture caused a small amount of a precipitate to form which was removed by filtration and the filtrate was concentrated in-vacuo to yield an oil which showed a stong absorption peak in the infrared region at 2200 cm.sup.1 consistent for the desired sulfonyl isocyanate. This highly reactive intermediate was used without further purification.

EXAMPLE 2

Methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-aminosulfonyl]-2-thiophenec arboxylate

To 1.23 g of 2-amino-4,6-dimethyl pyrimidine in 30 ml of anhydrous acetonitrile was added with stirring 2.7 g of 2-methoxycarbonyl-3-thiophene-sulfonylisocyanate. The mixture was heated to the boiling point, whereupon all of the insoluble material dissolved and the mixture was allowed to cool. After stirring for two hours the mixture was filtered to remove the desired product which had precipitated as a white solid. After washing with anhydrous ethyl ether the produce melted at 191.degree.-193.degree. with decomposition and showed absorption peaks by nuclear magnetic resonance at 3.8 ppm for the methoxy group, 2.44 ppm for the two methyl groups on the pyrimidine ring, a peak at 7.0 consistent for the hydrogen in the pyrimidine ring and a peak at 7.42 for the hydrogens on the thiophene ring. The infrared absorption spectrum showed absorption peaks at 1720 and 1700 cm-.sup.1 consistent for the two carbonyl groups present in the desired product.

EXAMPLE 3

Methyl 3 [[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-aminosulfonyl] -2-thiophenecarboxylate

To 1.5 g of 2-amino-4,6-dimethoxypyrimidine in 30 ml of anhydrous acetonitrile was added 2.7 g of 2-methoxycarbonyl-3-thiopnenesulfonyl isocyanate with stirring at ambient temperature. All of the solid reactant dissolved and after twenty minutes of stirring a preciptate started to form. After two hours the mixture was filtered and the solid which was washed with anhydrous ethyl ether, melted at 191.degree.-193.degree.. The solid showed peaks by nuclear magnetic resonance spectroscopy at 4.0 ppm and 3.8 ppm for the methoxy groups, 6.0 ppm for the H of pyrimidine and 7.6 ppm for the hydrogens on thiophene. The infrared absorption spectrum showed absorption peaks at 1730 and 1700 cm-.sup.1 consistent for the two carbonyl peaks in the desired product.

EXAMPLE 4

Methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiop henecarboxylate

To 1.4 g of 2-amino-4-methoxy-6-methylpyrimidine in 30 ml of anhydrous acetonitrile was added at ambient temperature, with stirring 3.6 g of 2-methoxycarbonyl-3-thiophenesulfonylisocyanate. The mixture was heated to the boiling point and then allowed to cool to ambient temperature. After stirring for sixteen hours the precipitate present in the mixture was filtered off and washed with anhydrous ethyl ether. The product thus obtained which melted at 165.degree.-173.degree. showed absorption peaks by infrared spectroscopy at 1720 and 1700 cm-.sup.1, consistent for the carbonyl groups in the desired product.

EXAMPLE 5

Methyl 3-[[(4,6-dimethyl-1,3,5-triazin-2-yl) aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate

To 1.23 g of 2-amino-4,6-dimethyl-1,3,5-triazine in 30 ml of anhydrous methylene chloride was added with stirring 2.7 g of 2-methoxycarbonyl-3-thiophenesulfonylisocyanate. The mixture was heated to the boiling point and allowed to cool and stir at ambient temperature for sixteen hours. The solid thus obtained was removed by filtration to yield 2.3 g of the crude desired product melting at 158.degree.-178.degree.. The product showed peaks at 1720 and 1700 cm-.sup.1, by infrared absorption spectroscopy, consistent for the desired product.

EXAMPLE 6

Methyl 3-[[(5,6 dimethyl-1,2,4-triazinyl-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarb oxylate

To 1.2 g of 3-amino-5,6-dimethyl-1,2,4-traizine in 30 ml of anhydrous methylene chloride was added with stirring 2.7 g of 2-methoxycarbonyl-3-thiophenesulfonylisocyanate. After stirring for 16 hours at ambient temperature the solution was filtered to remove some insoluble material and the filtrate evaporated to dryness. The residue thus obtained was triturated with ethyl ether and the insoluble product filtered to yield 2.9 g of the desired compound melting at 129.degree. with decomposition. Infrared analysis of this product showed absorption peaks at 1730 and 1700 cm-.sup.1 as expected for the desired product.

EXAMPLE 7

3-[[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]amino sulfonyl]-2-thiophene carboxylic acid

A solution of 1.0 g of methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiopheneca rboxylate in 10 ml of ethanol and 1 ml of 50% sodium hydroxide in water was stirred overnight at room temperature. To this was added icewater and aqueous hydrochloric acid until acidic, and the precipitate was filtered and washed first with acetone and then with methylene chloride. The product, 0.8 g, melted at 127.degree..

EXAMPLE 8

1-[3-[[(4-methoxy-6-methylpyrimidin-2-yl)aminocarbonyl]aminosulfonyl]thiene -2-yl carbonyl]pyrrolidone

To 2.5 ml of 2M-solution of trimethylaluminum in toluene was added 20 ml of methylene chloride and 400 .mu.l of pyrrolidine. To this solution was added 0.66 g of methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)amino carbonyl]aminosulfonyl]-2-thiophenecarboxylate. The resulting solution was stirred under nitrigen overnight at room temperature, quenched with 5N aqueous hydrochloric acid, and extracted with ethyl acetate. The residue obtained from evaporation of solvent was washed with ether to afford 0.6 g of product, mp 184.degree.-5.degree., which showed absorption peaks at 1.8-2.2 ppm and 3.2-3.8 ppm for the pyrrolidine ring and no methyl ester peak, and all other signals indicative of the desired product.

                                      TABLE I-a
    __________________________________________________________________________
     ##STR97##
    A'    R.sup.I      W R.sub.5
                            X     Y              m.p. (.degree.C.)
    __________________________________________________________________________
    H     CH.sub.3     O H  CH.sub.3
                                  Cl
    H     CH.sub.3     O H  H     H
    H     CH.sub.3     O H  Cl    Cl
    H     CH.sub.3     O H  OCH.sub.2 CH.sub.3
                                  CH.sub.2 CH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  CH.sub.2 CH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  CH.sub.3 CH.sub.2 OCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  (CH.sub.2).sub.4 OCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CN
    H     CH.sub.3     O H  OCH.sub.3
                                   ##STR98##
    H     CH.sub.3     O H  OCH.sub.3
                                  (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CF.sub.3
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CH.sub.2 Cl
    H     CH.sub.3     O H  OCH.sub.3
                                  CF.sub.3
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CCl.sub.3
    H     CH.sub.3     O H  OCH.sub.3
                                  (CH.sub.2).sub.4 Cl
    H     CH.sub.3     O H  OCH.sub.3
                                  (CH.sub.2).sub.3 Br
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CHCH.sub.2
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.2 CHCHCH.sub.2
    H     CH.sub.3     O H  CH.sub.3
                                  O(CH.sub.2).sub.2 OCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  O(CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H     CH.sub.3     O H  CH.sub.3
                                  O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H     CH.sub.3     O H  CH.sub.3
                                  O(CH.sub.2).sub.3 O(CH.sub.2).sub.2
                                  CH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR99##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR100##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR101##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR102##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR103##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR104##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR105##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR106##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR107##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR108##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR109##
    H     CH.sub.3     O H  CH.sub.3
                                  SCN
    H     CH.sub.3     O H  CH.sub.3
                                  N.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  NH.sub.2
    H     CH.sub.3     O H  CH.sub.3
                                  NHCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR110##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR111##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR112##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR113##
    H     CH.sub.3     O H  CH.sub.3
                                  NHCH.sub.2 CHCH.sub.2
    H     CH.sub.3     O H  CH.sub.3
                                  NHCH.sub.2 CHCHCH.sub.2
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR114##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR115##
    H     CH.sub.3     O H  CH.sub.3
                                  NH(CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR116##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR117##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR118##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR119##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR120##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR121##
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR122##
    H     CH.sub.3     O H  CH.sub.3
                                  OC.sub.2 H.sub.5
    H     CH.sub.3     O H  CH.sub. 3
                                  On-C.sub.3 H
    H     CH.sub.3     O H  CH.sub.3
                                  OCH(CH.sub.3).sub.2
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR123##
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2 CF.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2 CH.sub.2 Cl
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2 CH.sub.2 Br
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2 CCl.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2 CN
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR124##
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2CHCHCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2CCH
    H     CH.sub.3     O H  CH.sub.3
                                  OCH.sub.2CCCH.sub.2 Cl
    H     CH.sub.3     O H  CH.sub.3
                                   ##STR125##
    H     CH.sub.3     O H  CH.sub. 3
                                   ##STR126##
    H     CH.sub.3     O H  CH.sub.3
                                  SCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  SCH(CH.sub.3).sub.2
    H     CH.sub.3     O H  CH.sub.3
                                  Sn-C.sub.4 H.sub.9
    H     CH.sub.3     O H  CH.sub.3
                                  SCH.sub.2 CHCH.sub.2
    5-CH.sub.3
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-CH.sub.3
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Cl  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Cl  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Cl  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Br  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Br  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Br  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-n-C.sub.4 H.sub.9
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.5 CN
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CHCH(CH.sub.2).sub.2 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CCCH.sub.2 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CC(CH.sub.2).sub.3 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
           ##STR127##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR128##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR129##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR130##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR131##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR132##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR133##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR134##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR135##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR136##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR137##  O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     O H  OCH.sub.3
                                  SCH.sub.2CCH
    H     CH.sub.3     O H  OCH.sub.3
                                   ##STR138##
    H     CH.sub.3     O H  OCH.sub.3
                                  SCH.sub.2 CN
    H     CH.sub.3     S H  OCH.sub.3
                                  CH.sub.3
    H     CH.sub.3     S H  CH.sub.3
                                  CH.sub.3
    H     CH.sub.3     S H  OCH.sub.3
                                  CH.sub.3
    H     CH.sub.3     S H  OCH.sub.3
                                  CH.sub.3
    H     CH.sub.3     S CH.sub.3
                            OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     S CH.sub.3
                            CH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     S H  OCH.sub.3
                                  OC.sub.2 H.sub.5
    H     CH.sub.3     O CH.sub.3
                            OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     O CH.sub.3
                            CH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     O CH.sub.3
                            CH.sub.3
                                  CH.sub.3
    H     CH.sub.3     O CH.sub.3



                            CH.sub.3
                                  OCH.sub.2 CO.sub.2 CH.sub.3
    4-Cl  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    4-Cl  CH(CH.sub.3).sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    4-Cl  CH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    4-Br  C.sub.2 H.sub.5
                       O H  CH.sub.3
                                  OCH.sub.3
    4-CH.sub.3
          CH.sub.3 CH.sub.2 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    4-C.sub.2 H.sub.5
          CH(CH.sub.3).sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    4-n-C.sub.4 H.sub.9
          CH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    4-i-C.sub.3 H.sub.7
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-Cl  C.sub.2 H.sub.3
                       O H  CH.sub.3
                                  OCH.sub.3
    5-Br  CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-CH.sub.3
          CH(CH.sub.3).sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    H     C.sub.2 H.sub.5
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.3 CH.sub.3
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.4 CH.sub.3
                       O H  OCH.sub.3
                                  OCH.sub.3
    H
           ##STR139##  O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.5 CH.sub.3
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CHCHCH.sub.3
                       O H  OCH.sub.3
                                  OCH.sub. 3
    H     CH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CHCHCH(.sub.3).sub.2
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.3 Cl
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.3).sub.5 Cl
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.6 OCH.sub.3
                       O H  OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CN  O H  OCH.sub.3
                                  OCH.sub.3
    4-OCH.sub.3
          CH.sub.3     O H  CH.sub.3
                                  CH.sub.3
    5-OCH.sub.3
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    4-NO.sub.2
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-NO.sub.2
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    4-CF.sub.3
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    5-CF.sub.3
          CH.sub.3     O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CCl.sub.3
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.6 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CBr.sub.3
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub. 4 Br
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.6 Br
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.6 F
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.4 F
                       O H  CH.sub.3
                                  OCH.sub.3
    H     (CH.sub.2).sub.3 F
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CF.sub.3
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 CN  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR140##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR141##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR142##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR143##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR144##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR145##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR146##  O H  CH.sub.3
                                  OCH.sub.3
    H
           ##STR147##  O H  CH.sub.3
                                  OCH.sub.3
    `-H   CH.sub.2 OCH.sub.3
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 OC.sub.2 H.sub.5
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 OCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                                  OCH.sub.3
    H     CH.sub.2 On-C.sub.4 H.sub.9
                       O H  CH.sub.3
                                  OCH.sub.3
    H     H            O H  CH.sub.3
                                  CH.sub.3
    H     H            O H  CH.sub.3
                                  OCH.sub.3
    H     H            O H  OCH.sub.3
                                  OCH.sub.3
    H     CH.sub.3     O H  CH.sub.3
                                  CH.sub.3       191-193
    H     CH.sub.3     O H  OCH.sub.3
                                  OCH.sub.3      191-193
    H     CH.sub.3     O H  OCH.sub.3
                                  CH.sub.3       165-173
    H     CH.sub.2 C.sub.6 H.sub.5
                       O H  CH.sub.3
                                  CH.sub.3       133-136
    H     CH(CH.sub.3).sub.2
                       O H  OCH.sub.3
                                  OCH.sub.3      155-160
    H     CH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                                  OCH.sub.3      164-165
    H     CH(CH.sub.3).sub.2
                       O H  CH.sub.3
                                  OCH.sub. 3     153-161
    H     CH(CH.sub.3)C.sub.2 H.sub.5
                       O H  CH.sub.3
                                  OCH.sub.3      146-156
    H     CH(CH.sub.3)CHCH.sub.2
                       O H  CH.sub.3
                                  OCH.sub.3      152-154
    H     CH(CH.sub.3)CCH
                       O H  CH.sub.3
                                  OCH.sub.3      167-173
    H     CH.sub.3     O H  CH.sub.3
                                  CF.sub.3       171-175
    H     CH.sub.3     O H  CH.sub.3
                                  SCH.sub.3      128-142
    H     CH.sub.3     O H  CH.sub.3
                                  CH.sub.2 OCH.sub.3
                                                 183-187
    H     CH.sub.3     O H  CH.sub.3
                                  Cl             155-158
    H     CH.sub.3     O H  CH.sub.3
                                  N(CH.sub.3).sub.2
                                                 225-228
    H     CH.sub.3     O H  Cl    N(CH.sub.3).sub.2
                                                 205-207
    H     CH.sub.3     O H  CH.sub.3
                                  CH.sub.3       198-199
    H     CH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                                  CH.sub.3       173-175(d)
    H     CH.sub.2 CHCH.sub.2
                       O H  OCH.sub.3
                                  OCH.sub.3      140-145(d)
    H     CH.sub.3     O H  CH.sub.3
                                  H              184-185(d)
    H     CH.sub.3     O H  CH.sub.3
                                  C.sub.2 H.sub.5
                                                 160-169
    H     CH.sub.3     O H  CH.sub.3
                                  CH(CH.sub.3).sub.2
                                                 130-139
    H     CH(CH.sub.3)CCH
                       O H  CH.sub.3
                                  CH.sub.3        --
    H     CH.sub.3     O H  CH.sub.3
                                  N(CH.sub.3)OCH.sub.3
                                                 150-154(d)
    __________________________________________________________________________


              TABLE I-b
    ______________________________________
     ##STR148##
                                               m.p.
    A'  R.sup.I
               W     R.sub.5
                         X        Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3 Cl
    H   CH.sub.3
               O     H   H        H
    H   CH.sub.3
               O     H   Cl       Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                  CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                   ##STR149##
    H   CH.sub.3
               O     H   OCH.sub.3
                                  (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                  (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                  (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3 O(CH.sub.2).sub. 2 OCH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3 CH.sub.3     179-
                                               181(d)
    H   CH.sub.3
               O     H   OCH.sub.3
                                  CH.sub.3     149-
                                               159(d)
    H   CH.sub.3
               O     H   OCH.sub.3
                                  OCH.sub.3    189-
                                               190(d)
    ______________________________________


                                  TABLE I-c
    __________________________________________________________________________
     ##STR150##
    A'  R.sup.I
            W  R.sub.5
                  X      Y          m.p. (.degree.C.)
    __________________________________________________________________________
    H   CH.sub.3
            O  H  CH.sub.3
                         Cl
    H   CH.sub.3
            O  H  H      H
    H   CH.sub.3
            O  H  Cl     Cl
    H   CH.sub.3
            O  H  OCH.sub.2 CH.sub.3
                         CH.sub.2 CH.sub.3
    H   CH.sub.3
            O  H  CH.sub.3
                         CH(CH.sub.3).sub.2
    H   CH.sub.3
            O  H  CH.sub.3
                         CH.sub.2 CH.sub.3
    H   CH.sub.3
            O  H  CH.sub.3
                         CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
            O  H  CH.sub.3
                         (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
            O  H  CH.sub.3
                         (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CN
    H   CH.sub.3
            O  H  OCH.sub.3
                          ##STR151##
    H   CH.sub.3
            O  H  OCH.sub.3
                         (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CF.sub.3
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
            O  H  OCH.sub.3
                         CF.sub.3
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CCl.sub.3
    H   CH.sub.3
            O  H  OCH.sub.3
                         (CH.sub.2).sub.4 Cl
    H   CH.sub.3
            O  H  OCH.sub.3
                         (CH.sub.2).sub.3 Br
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CHCH.sub.2
    H   CH.sub.3
            O  H  OCH.sub.3
                         CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
            O  H  CH.sub.3
                         O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
            O  H  CH.sub.3
                         O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
            O  H  CH.sub.3
                         O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H   CH.sub.3
            O  H  CH.sub.3
                         OCH.sub.3  182-183.5
    H   CH.sub.3
            O  H  CH.sub.3
                         CH.sub.3   169-172(d)
    H   CH.sub.3
            O  H  OCH.sub.3
                         OCH.sub.3  179-181
    H   CH.sub.3
            O  H  CH.sub.3
                         CH.sub.2 OCH.sub.3
                                    154-157(d)
    5-C.sub.2 H.sub.5
        CH.sub.3
            O  H  CH.sub.3
                         CH.sub.3   180-185
    5-C.sub.2 H.sub.5
        CH.sub.3
            O  H  CH.sub.3
                         OCH.sub.3  150-154(d)
    5-C.sub.2 H.sub.5
        CH.sub.3
            O  H  OCH.sub.3
                         OCH.sub.3  158-161
    __________________________________________________________________________


                                  TABLE I-d
    __________________________________________________________________________
     ##STR152##
    A'
      R.sup.I W R.sub.5
                    X     Y          m.p. (.degree.C.)
    __________________________________________________________________________
    H CH.sub.3
              O H   CH.sub.3
                          Cl
    H CH.sub.3
              O H   H     H
    H CH.sub.3
              O H   Cl    Cl
    H CH.sub.3
              O H   OCH.sub.2 CH.sub.3
                          CH.sub.2 CH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          CH(CH.sub.3).sub.2
    H CH.sub.3
              O H   CH.sub.3
                          CH.sub.2 CH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          CH.sub.2 OCH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          CH.sub.3 CH.sub.2 OCH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          (CH.sub.2).sub.4 OCH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          (CH.sub. 2).sub.2 OC.sub.2 H.sub.5
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CN
    H CH.sub.3
              O H   OCH.sub.3
                           ##STR153##
    H CH.sub.3
              O H   OCH.sub.3
                          (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CF.sub.3
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CH.sub.2 Cl
    H CH.sub.3
              O H   OCH.sub.3
                          CF.sub.3
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CCl.sub.3
    H CH.sub.3
              O H   OCH.sub.3
                          (CH.sub.2).sub.4 Cl
    H CH.sub.3
              O H   OCH.sub.3
                          (CH.sub.2).sub.3 Br
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CHCH.sub.2
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 CHCHCH.sub.2
    H CH.sub.3
              O H   CH.sub.3
                          O(CH.sub.2).sub.2 OCH.sub.3
    H CH.sub.3
              O H   CH.sub.3
                          O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H CH.sub.3
              O H   CH.sub.3
                          O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H CH.sub. 3
              O H   CH.sub.3
                          CH.sub.3   158-171
    H CH.sub.3
              O H   OCH.sub.3
                          OCH.sub.3  181-183
    H CH.sub.3
              O H   CH.sub.3
                          OCH.sub.3  166-170
    H CH(CH.sub.3).sub.2
              O H   CH.sub.3
                          CH.sub.3   195-196(d)
    H CH(CH.sub.3).sub.2
              O H   CH.sub.3
                          OCH.sub.3  179-181(d)
    H CH(CH.sub.3).sub.2
              O H   OCH.sub.3
                          OCH.sub.3  178-180(d)
    H CH.sub.2 CHCH.sub.2
              O H   CH.sub.3
                          OCH.sub.3  142-146(d)
    H CH.sub.2 CHCH.sub.2
              O H   OCH.sub.3
                          OCH.sub.3  151-155(d)
    H CH.sub.3
              O H   OCH.sub.3
                          N(CH.sub.3).sub.2
                                     173-175
    H CH.sub.3
              O H   OCH.sub.3
                          CH.sub.2 OCH.sub.3
                                     179-181
    H CH.sub.3
              O CH.sub.3
                    OCH.sub.3
                          OCH.sub.3  185-187
    H CH.sub.3
              O CH.sub.3
                    CH.sub.3
                          Cl         134-138
    H CH.sub.3
              O CH.sub.3
                    OCH.sub.3
                          CH.sub.3   139-145
    H CH.sub.3
              O OCH.sub.3
                    OCH.sub.3
                          OCH.sub.3  175-177
    __________________________________________________________________________


                                  TABLE I-e
    __________________________________________________________________________
     ##STR154##
    A'
      R.sup.I
             W R.sub.5
                 X     Y           m.p.(.degree.C.)
    __________________________________________________________________________
    H CH.sub.3
             O H CH.sub.3
                       Cl
    H CH.sub.3
             O H H     H
    H CH.sub.3
             O H Cl    Cl
    H CH.sub.3
             O H OCH.sub.2 CH.sub.3
                       CH.sub.2 CH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH(CH.sub.3).sub.2
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.2 CH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.3 CH.sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       (CH.sub.2).sub.4 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CN
    H CH.sub.3
             O H OCH.sub.3
                        ##STR155##
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CF.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CH.sub.2 Cl
    H CH.sub.3
             O H OCH.sub.3
                       CF.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CCl.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.4 Cl
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.3 Br
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CHCHCH.sub.2
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CHCH.sub.2
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.3    184-187(d)
    H CH.sub.3
             O H CH.sub.3
                       OCH.sub.3   196-198(d)
    H CH.sub.3
             O H OCH.sub.3
                       OCH.sub.3   192-195
    H CH(CH.sub.3).sub.2
             O H CH.sub.3
                       CH.sub.3    155-157
    H CH(CH.sub.3).sub.2
             O H CH.sub.3
                       OCH.sub.3   166-170
    H CH(CH.sub.3).sub.2
             O H OCH.sub.3
                       OCH.sub.3   176-177
    __________________________________________________________________________


                                  TABLE I-f
    __________________________________________________________________________
     ##STR156##
    A'
      R.sup.I
             W R.sub.5
                 X     Y           m.p.(.degree.C.)
    __________________________________________________________________________
    H CH.sub.3
             O H CH.sub.3
                       Cl
    H CH.sub.3
             O H H     H
    H CH.sub.3
             O H Cl    Cl
    H CH.sub.3
             O H OCH.sub.2 CH.sub.3
                       CH.sub.2 CH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH(CH.sub.3).sub.2
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.2 CH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.3 CH.sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       (CH.sub.2).sub.4 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CN
    H CH.sub.3
             O H OCH.sub.3
                        ##STR157##
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CF.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CH.sub.2 Cl
    H CH.sub.3
             O H OCH.sub.3
                       CF.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CCl.sub.3
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.4 Cl
    H CH.sub.3
             O H OCH.sub.3
                       (CH.sub.2).sub.3 Br
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CHCH.sub.2
    H CH.sub.3
             O H OCH.sub.3
                       CH.sub.2 CHCHCH.sub.2
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.2 OCH.sub.3
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H CH.sub.3
             O H CH.sub.3
                       O(CH.sub.2).sub.2 OCH(CH.sub. 3).sub.2
    H CH.sub.3
             O H CH.sub.3
                       CH.sub.3    165-175
    H CH.sub.3
             O H CH.sub.3
                       OCH.sub.3   170-72(d)
    H CH.sub.3
             O H OCH.sub.3
                       OCH.sub.3   --
    H CH(CH.sub.3).sub.2
             O H CH.sub.3
                       CH.sub.3    158-160
    H CH(CH.sub.3).sub.2
             O H CH.sub.3
                       OCH.sub.3   106-111
    H CH(CH.sub.3).sub.2
             O H OCH.sub.3
                       OCH.sub.3   165-167
    __________________________________________________________________________


              TABLE I-g
    ______________________________________
     ##STR158##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR159##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub.3 ).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3     194-196
    H   CH.sub.3
               O     H   CH.sub.3
                                 OCH.sub.3    162-165
    H   CH.sub.3
               O     H   OCH.sub.3
                                 OCH.sub.3    205-207
    ______________________________________


              TABLE I-h
    ______________________________________
     ##STR160##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR161##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.3     168-170
    H   CH.sub.3
               O     H   OCH.sub.3
                                 OCH.sub.3    164-167
    ______________________________________


              TABLE I-i
    ______________________________________
     ##STR162##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR163##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub. 3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3     189-190
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.3     189-190
    H   CH.sub.3
               O     H   OCH.sub.3
                                 OCH.sub.3    180-182
    ______________________________________


              TABLE I-j
    ______________________________________
     ##STR164##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub. 4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR165##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 OCH.sub.3    160-163
    H   CH.sub.3
               O     H   OCH.sub.3
                                 OCH.sub.3    173-175
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3     174-176
    ______________________________________


              TABLE I-k
    ______________________________________
     ##STR166##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub. 3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR167##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    ______________________________________


              TABLE I-l
    ______________________________________
     ##STR168##
                                              m.p.
    A'  R.sup.I
               W     R.sub.5
                         X       Y            (.degree.C.)
    ______________________________________
    H   CH.sub.3
               O     H   CH.sub.3
                                 Cl
    H   CH.sub.3
               O     H   H       H
    H   CH.sub.3
               O     H   Cl      Cl
    H   CH.sub.3
               O     H   OCH.sub.2 CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH(CH.sub.3).sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 CH.sub.3 CH.sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 (CH.sub.2).sub.4 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub. 3
                                 (CH.sub.2).sub.2 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CN
    H   CH.sub.3
               O     H   OCH.sub.3
                                  ##STR169##
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 CO.sub.2 CH.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CO.sub.2 C.sub.2 H.sub.5
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CH.sub.2 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CF.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CCl.sub.3
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.4 Cl
    H   CH.sub.3
               O     H   OCH.sub.3
                                 (CH.sub.2).sub.3 Br
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCH.sub.2
    H   CH.sub.3
               O     H   OCH.sub.3
                                 CH.sub.2 CHCHCH.sub.2
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH.sub.3
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.3 OC.sub.2 H.sub.5
    H   CH.sub.3
               O     H   CH.sub.3
                                 O(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
    ______________________________________


              TABLE II-a
    ______________________________________
     ##STR170##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p.(.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-b
    ______________________________________
     ##STR171##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-c
    ______________________________________
     ##STR172##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
                                             129.degree. (d)
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-d
    ______________________________________
     ##STR173##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
                                             126-133.degree.
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-e
    ______________________________________
     ##STR174##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-f
    ______________________________________
     ##STR175##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-g
    ______________________________________
     ##STR176##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub. 2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-h
    ______________________________________
     ##STR177##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-i
    ______________________________________
     ##STR178##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-j
    ______________________________________
     ##STR179##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub. 3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-k
    ______________________________________
     ##STR180##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub. 2 H.sub.5
                                       CH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          O           H     OCH.sub.3
                                 OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE II-l
    ______________________________________
     ##STR181##
    A'    R.sup.I     W     R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    H     H
    H     CH.sub.3    O     H    H     OCH.sub.3
    H     CH.sub.3    O     H    H     CH.sub.3
    H     CH.sub.3    O     H    Cl    H
    H     CH.sub.3    O     H    Cl    OCH.sub.3
    H     CH.sub.3    O     H    Cl    CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       H
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       H
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       CH.sub. 3
    H     CH.sub.3    O     H    CH.sub.3
                                       H
    H     CH.sub.3    O     H    CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-Br  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-C.sub.2 H.sub.5
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     CH   OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    S     H    H     H
    H     CH(CH.sub.3).sub.2
                      S     H    CH.sub.3
                                       CH.sub.3
    ______________________________________


              TABLE III-a
    ______________________________________
     ##STR182##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE III-b
    ______________________________________
     ##STR183##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
                                             147-155(d)
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE III-c
    ______________________________________
     ##STR184##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub. 3 S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE III-d
    ______________________________________
     ##STR185##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
                                             180-182.degree.
    5-CH.sub.3
           O         H      O    CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE III-e
    ______________________________________
     ##STR186##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
                                             175.degree.(d)
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE III-f
    ______________________________________
     ##STR187##
    A'     R.sup.I   W      R.sub.5
                                 X.sub.11
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H      CH.sub.3  O      H    CH.sub.2
                                       H
    H      CH.sub.3  O      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  O      H    CH.sub.2
                                       CH.sub.3
    H      CH.sub.3  O      H    O     H
    H      CH.sub.3  O      H    O     OCH.sub.3
    H      CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-CH.sub.3
           CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    5-Cl   CH.sub.3  O      H    O     CH.sub.3
    H      CH.sub.3  S      H    CH.sub.2
                                       OCH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH.sub.3  S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     S      H    O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      H    O     CH.sub.3
    H      CH.sub.3  O      CH.sub.3
                                 O     CH.sub.3
    H      CH(CH.sub.3).sub.2
                     O      CH.sub.3
                                 O     CH.sub.3
    ______________________________________


              TABLE IV-a
    ______________________________________
     ##STR188##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub. 3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE IV-b
    ______________________________________
     ##STR189##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE IV-c
    ______________________________________
     ##STR190##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE IV-d
    ______________________________________
     ##STR191##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE IV-e
    ______________________________________
     ##STR192##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.5
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE IV-f
    ______________________________________
     ##STR193##
                                               m.p.
    A'    R.sup.I     W     R.sub.5
                                 X     Y       (.degree.C.)
    ______________________________________
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     H    CH.sub.3
                                       CH.sub.2 OCH.sub.3
    H     CH.sub.3    O     H    OC.sub.2 H.sub.5
                                       C.sub.2 H.sub.5
    H     CH.sub.3    S     H    OCH.sub.3
                                       CH.sub.3
    H     CH.sub.3    S     H    CH.sub.3
                                       CH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 CH.sub.3
                                       OCH.sub.3
    H     CH.sub.3    O     CH.sub.3
                                 OCH.sub.3
                                       OCH.sub.3
    5-Cl  CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    CH.sub.3
                                       CH.sub.3
    5-CH.sub.3
          CH.sub.3    O     H    OCH.sub.3
                                       OCH.sub.3
    H     C.sub.2 H.sub.5
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH(CH.sub.3).sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    H     CH.sub.2 CHCH.sub.2
                      O     H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE V
    ______________________________________
     ##STR194##
    A'  R.sup.I   R.sub.5
                        X      Y      Z      m.p. (.degree.C.)
    ______________________________________
    H   CH.sub.3  H     CH.sub.3
                               CH.sub.3
                                      CH
    H   CH.sub.3  H     CH.sub.3
                               OCH.sub.3
                                      CH
    H   CH.sub.3  H     CH.sub.3
                               OC.sub.2 H.sub.5
                                      CH
    H   CH.sub.3  H     OCH.sub.3
                               OCH.sub.3
                                      CH
    H   CH(CH.sub.3).sub.2
                  H     OCH.sub.3
                               CH.sub.3
                                      N
    H   CH.sub.2 CH.sub.2 Cl
                  H     OCH.sub.3
                               OCH.sub.3
                                      N
    H   CH.sub.3  H     CH.sub.3
                               CH.sub.3
                                      N
    H   CH.sub.3  H     CH.sub.3
                               CH.sub.3
                                      CCH.sub.3
    H   CH.sub.3  H     CH.sub.3
                               OCH.sub.3
                                      CCH.sub.3
    ______________________________________
 
			

			


			



		


Adjustable valve for pipette gun
Agent system



Air-fuel ratio detecting system
Alcohol synthesis



Analog to digital converter
Anti-skid brake system



Antibodies to plasmodium falciparum
Antimicrobial toilet bars



Apparatus for analyzing biological specimens
Apparatus for cleaning surfaces



Apparatus for collecting cultures
Apparatus for mixing plastics



Apparatus for mounting advertisement notice
Apparatus for performing work functions



Apparatus for sorting documents
Apparatus for transporting bulk materials



Archery cross hair sight protector
Arm exerciser



Asphalt heater
Asynchronous pseudo SRAM



Athletic undergarment
Attrition resistant catalysts



Automatic circuit board tester
Automatic vehicle deceleration



Ball bearing
Ball joint



Ball valve
Barbed anchor pile



Benzimidazole derivatives with antihistaminic activity
Biodegradable non-toxic gear oil



Block copolymer composition
Body positioning device



Boolean gate definition
Braking device particularly for skates



Brassiere
Broad-band substrate-wave-coupled electro-optic modulator



Building element
Built in board resistors



Calendar pad stand
Caliper



Camera driving circuit
Car cover and anchoring assembly



Car wash mop
Catalyst for olefin polymerization



Cigarette smoking device
Cleaving apparatus



Clock with constellation display
Closure cap



Closure for telecommunications cable
Coating Apparatus



Color temperature control circuit
Combustor for waste gas treatment



Compact tailgate lifter
Compound hair roller



Container venting arrangement
Container with cover lockable thereon



Control for engine
Conveyors system with volume sharing



Coordinate input device with display
Core lifting chuck



Creeper
Cuffed aircraft propeller



Cut-off gauge for saw tables
Cycle lamp and attachment therefor



Cytomegalovirus proteinase
Daunosamine nucleosides



Development system
Device for eliminating malodorous smells



Device for mounting an item
Differential hair curler



Digital audio tape recorder
Digital camera



Digital video image splitter
Direct station selection circuit



Dispensing device for radionuclide generators
Disperse dyes



Display control device and method
Divide-by-two frequency divider



Drilling device
Drive circuit for resonant motors



Dynamic preloading of web pages
Electric igniter assembly



Electric stapler
Electrical cable connector



Electrical ground fault detection apparatus
Electrically heatable catalytic converter insert



Emergency steering wheel braking system
Enantiomeric resolution



Endarterectomy method and apparatus
Engagement ring bracelet



Enhancing liquid jet erosion
Exposure method



External flash control system
Fabric conditioning compositions



Far infrared barbecue stove
Fastening device



Fiber quality monitor
Filter cleaning device



Fireplace heating unit
Fishing rod holder



Flame-retardant nylon resin composition
Flexible bag taping machine



Flexible lead chloride cathode construction
Flow regulator



Flue for water heater
Fluid diverting assembly



Fluorided composite catalyst
Fragrance pro-accords



Freezer
Frequency conversion system



Gas collecting apparatus
Gas discharge laser



Gas-cleaning equipment and its use
Gear box assembly



Generation of uniformly-distributed plasma
Generator housing



Glass repair apparatus
Golf grip training device



Golf training device
Graphic display area classification



Heating apparatus for vehicle
High density flash EPROM



High friction brake shoe assembly
High voltage waveform generator



High-adhesion conductors
High-power III-V semiconductor device



Hinge structure for automobile hoods
HIV protease inhibitors



Hockey helmet with self-adjusting padding
Increment/decrement sampling phase shifter



Induction heating apparatus
Inflating device for use single-handed



Inflator/deflator accessory for air compressor
Infusion devices and method



Inline dispersal valve
Jaw assembly for endoscopic instruments



Ladder stabilizer
Large amplitude sinusoidal voltammetry



LiClO.sub.4 Containing propellant compositions
Light bulb changer



Liquid crystal display
Liquid crystal display device



Liquid operated clock
Load responsive valve assemblies



Locking mechanism for vending machines
Low pressure transducer



Machines for classifying pharmaceutical capsules
Magnetic sensor integrated with CMOS



Manchester pattern fault recognition
Medical X-ray examination device



Method for reclaiming rubber
Method of continuously wrapping products



Method of controlling reel drive
Method of manufacturing three-dimensional compact



Method of producing copper-iron-aluminum catalysts
Method of redrawing metal cup



Methods for vessel cannulation
Mice lacking expression of osteoprotegerin



Microstrip wide band antenna
Mobile floor crane



Mobile sound field correcting device
Model rocket car



Modification of soy isolate
Motor vehicle bumper



Motorcycle towing apparatus
Mousse product



Multi-function pipe machining apparatus
Multi-lug socket tool



Multi-size photoreceptor flange bearing
Multi-story tower for goods display



Multifunctional bumper assembly
Multilayer capacitor



Multiple reflection optical system
Multiple stage hydrocarbon conversion process



Multiplex data communication system
Multivalent antigen-binding proteins



N-Substituted alkynyl anilines
Nanophase dental prosthetics and method



Navigational angle-measurement device
Needle protector sheath



Net posts for ball games
New organo-aluminum antiperspirant compositions



Nifedipine combination preparation
Non-fouling print stylus



Oil funnel assembly
Open back acoustic speaker module



Optical color printer assembly
Optical device



Optical fiber decorative article
Optical recording medium



Optimization of information bases
Outdoor fan system



Panel lifter with antidrop protection
Panels for constructing swimming pools



Penile implantation prosthesis
Permanently lubricated bearing cartridge



Photo-induced DNA-cleaving agents
Photographic composite board



Photosensitive material processing apparatus
Pigment composition



PIM latch/extractor
Pipeline identification



Piperazine derivatives
Plant watering device



Plasma catalysis of carbon nanofibers
Plasma gun with adjustable cathode



Plastic molded center tube assembly
Poly-(-2-aminoalkyl)polyamines



Polyarylene sulfide molding composition
Portable exercise machine



Portable eye examination system cart
Powdered material parting agent



Power transmission
Precision casting titanium aluminide



Preparation of substituted benzophenones
Pressure swing adsorption process



Process for preparing .alpha.-ketocarboxylic acids
Process for preparing 4-substituted imidazo[1,2-a]quinoxalines



Process for producing ammonium polythimolybdate
Process for producing fluorinated catalysts



Process for producing pulse generator
Process for purifying aminosulfenylcarbamate derivatives



Process for whitening kaolin
Production of aqueous polymer compositions



Production of metallic powder
Putting skill game



Radiation-sensitive resin composition
Raster scanner variable-frequency clock circuit



Rattle-free door latch
Regulated DC power supply



Repatterned integrated circuit chip package
Retaining wall anchor system



Reversible door frame threshold
Roof ventilator



Rotary adsorption/desorption gas treating apparatus
Ruggedized tradesworkers radio



Safety harness
Satellite communication routing arbitration techniques



Secure boot
Self resonant scanning device



Semiconductor chip carrier system
Semiconductor memory device



Sensor with improved drift stability
Shaving apparatus



Shock absorber
Shower head



Shutter device
Simulated moving bed reaction process



Single barrel externally powdered gun
Ski goggles



Slider window assembly
Snap-fit-button



Socket-wrench removable oil filter
Sod harvester



Solar control safety window
Soldering method and soldering apparatus



Speed change device
Staged anaerobic reactor



Steam generation apparatus and methods
Stent pattern with figure-eights



Stitching assembly for selvedging machine
Strand casting process



Structure for growing mushrooms
Sunblocking polymers and their formulation



Surgical probe apparatus and system
Swimming pool alarm



Synergistic germicidal compositions containing 3,5-dimethyl-4-chlorophenol
System for network resource management



Tacky-surface animal repeller
Tag pin



Tamburello
Tape measure endpiece



Telephone keypad input technique
Tent



Toilet tank flush control
Toner and developer compositions



Tonometer transducer positioning system
Torque transmitting apparatus



Transfer apparatus
Transformer with superconducting windings



Transgenic model of heart failure
Tree shear



Tricyclo[6.4.0.0.sup.2,7 ] dodecane-3,6-diphenyl-1,8,4,5-tetracarboxylic acid dianhydrides
Triorganotin cyanometallate compounds



Trouble lamp
Truck mounted load scale



Two-cycle engine
Umbilical safety joint



Unfurled side impact air bag
Universal joint prosthesis with cap



Urine control device
Variable microwave cold/warm noise source



Variable resistor
Vehicle disabling device



Vehicle propulsion system
Vehicular alternating current dynamo



Vermicular expanded graphite composite material
Vertical card file



Video pedobarograph system
Wafer chamfering machine



Webbing wind-up force limiting apparatus
Weighing and packing system



Welded austenitic steel pipe assembly
Well perforating apparatus



Wine dispenser
Work transport system
















		


              TABLE VI
    ______________________________________
     ##STR195##
                                               m.p.
    A'  R.sup.I
               WR.sup.IV     X     Y     Z     (.degree.C.)
    ______________________________________
    H   CH.sub.3
               OCH.sub.3     CH.sub.3
                                   CH.sub.3
                                         N
    H   CH.sub.3
               OC.sub.2 H.sub.5
                             OCH.sub.3
                                   CH.sub.3
                                         N
    H   CH.sub.3
               OCH.sub.2 CHCH.sub.2
                             OCH.sub.3
                                   CH.sub.3
                                         N
    H   CH.sub.3
               OCH.sub.3     OCH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OCH.sub.3     CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OCH(CH.sub.3).sub.2
                             CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OC.sub.2 H.sub.5
                             CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OCH.sub.3     CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               O(CH.sub.2).sub.3 CH.sub.3
                             CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OCH.sub.2 CHCHCH.sub.3
                             CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               OC.sub.2 H.sub.5
                             CH.sub.3
                                   CH.sub.3
                                         CCH.sub.3
    H   CH.sub.3
               SCH.sub.3     CH.sub.3
                                   OCH.sub.3
                                         N
    H   CH.sub.3
               SC.sub.2 H.sub.5
                             CH.sub.3
                                   OCH.sub.3
                                         N
    H   CH.sub.3
               SCH.sub.2 CHCH.sub.2
                             CH.sub.3
                                   CH.sub.3
                                         CH
    H   CH.sub.3
               S(CH.sub.2).sub.4 CH.sub.3
                             CH.sub.3
                                   CH.sub.3
                                         CH
    ______________________________________


                                  TABLE VII-a
    __________________________________________________________________________
     ##STR196##
    A'  QR.sup.I      W R.sub.5
                           X   Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3     O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                      O H  CH.sub.3
                               OCH.sub.3
         ##STR197##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR198##   O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                      O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                      O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2CCC.sub.2 H.sub.5
                      O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub.4 Cl
                      O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN  O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                      O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                      O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                      O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                      O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR199##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR200##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR201##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR202##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR203##   O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2      O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR204##   O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CN).sub.2
                      O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                      O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                      O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR205##   O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CHCH.sub.2).sub.2
                      O H  CH.sub.3
                               OCH.sub.3
    5-Cl
         ##STR206##   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
         ##STR207##   O H  CH.sub.3
                               OCH.sub.3
    5-Br
        NHCH.sub.3    O H  CH.sub.3
                               CH.sub.3
    5-CH.sub.3
        NHC.sub.2 H.sub.5
                      O H  CH.sub.3
                               CH.sub.3
    5-CH.sub.3
        NHCH(CH.sub.3).sub.2
                      O H  CH.sub.3
                               CH.sub.3
    H
         ##STR208##   O H  CH.sub.3
                               CH.sub.3
    H   NH(CH.sub.2).sub.5 CH.sub.3
                      O H  CH.sub.3
                               CH.sub.3
    H   NH(CH.sub.2)OCH.sub.3
                      O H  CH.sub.3
                               CH.sub.3
    H   NH(CH.sub.2).sub.3 OC.sub.2 H.sub.5
                      O H  CH.sub. 3
                               CH.sub.3
    H   NH(CH.sub.2).sub.2 OCH(CH.sub.3).sub.2
                      O H  CH.sub.3
                               CH.sub.3
    H
         ##STR209##   O H  CH.sub.3
                               CH.sub.3
    H   NHCH.sub.2 CHCH.sub.2
                      O CH.sub.3
                           CH.sub.3
                               CH.sub.3
    H   NHCH.sub.2 CHCHC.sub.2 H.sub.5
                      O H  CH.sub.3
                               CH.sub.3
    H
         ##STR210##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR211##   O CH.sub.3
                           CH.sub.3
                               CH.sub.3
    H
         ##STR212##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR213##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR214##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR215##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR216##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR217##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR218##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR219##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR220##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR221##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR222##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR223##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR224##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR225##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR226##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR227##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR228##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR229##   O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR230##   O H  CH.sub.3
                               CH.sub.3
    H
         ##STR231##   O H  OCH.sub.3
                               CH.sub.3
    H   NHOC.sub.2 H.sub.5
                      O H  OCH.sub.3
                               CH.sub.3
                                   159-162
    H   N(CH.sub.3)OCH.sub.3
                      O H  OCH.sub.3
                               OCH.sub.3
                                   177-179(d)
    H   N(CH.sub.3)OCH.sub.3
                      O H  CH.sub.3
                               OCH.sub.3
                                   180-182.5
    H   NHOCH.sub.3   O H  CH.sub.3
                               CH.sub.3
                                   172-174
    H   N(CH.sub.3)OCH.sub.3
                      O H  CH.sub.3
                               CH.sub.3
                                   150-154
    H
         ##STR232##   O H  CH.sub.3
                               CH.sub.3
                                   205-205.5
    H
         ##STR233##   O H  CH.sub.3
                               CH.sub.3
                                   167-170
    H
         ##STR234##   O H  CH.sub.3
                               CH.sub.3
    __________________________________________________________________________


              TABLE VII-b
    ______________________________________
     ##STR235##
                                               m.p.
    A'    QR.sup.I        W     R.sub.5
                                    X    Y     (.degree.C.)
    ______________________________________
    H     SCH.sub.3       O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH(CH.sub.3).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
           ##STR236##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR237##     O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CHCH.sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CHCHC.sub.2 H.sub.5
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2CCC.sub.2 H.sub.5
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     S(CH.sub.2).sub.4 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CN    O     H   CH.sub.3
                                         OCH.sub.3
    5-Cl  S(CH.sub.2).sub.2 OCH.sub.3
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-Cl  S(CH.sub.2).sub.4 OCH.sub.3
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-CH.sub.3
          SCH.sub.2 CHCHCH.sub.2 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-C.sub.2 H.sub.5
          SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR238##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR239##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR240##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR241##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR242##     O     H   CH.sub.3
                                         OCH.sub.3
    H     NH.sub.2        O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR243##     O     H   CH.sub.3
                                         OCH.sub.3
    H     N(CH.sub.2 CN).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     N(CH.sub.2 CH.sub.2 CN).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     N(C.sub.2 H.sub.5).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR244##     O     H   CH.sub.3
                                         OCH.sub.3
    ______________________________________


              TABLE VII-c
    ______________________________________
     ##STR245##
                                               m.p.
    A'    QR.sup.I        W     R.sub.5
                                    X    Y     (.degree.C.)
    ______________________________________
    H     SCH.sub.3       O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH(CH.sub.3).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
           ##STR246##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR247##     O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CHCH.sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CHCHC.sub.2 H.sub.5
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2C CC.sub.2 H.sub.5
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     S(CH.sub.2).sub.4 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     SCH.sub.2 CN    O     H   CH.sub.3
                                         OCH.sub.3
    5-Cl  S(CH.sub.2).sub.2 OCH.sub.3
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-Cl  S(CH.sub.2).sub.4 OCH.sub.3
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-CH.sub.3
          SCH.sub.2 CHCHCH.sub.2 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    5-C.sub.2 H.sub.5
          SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                          O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR248##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR249##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR250##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR251##     O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR252##     O     H   CH.sub.3
                                         OCH.sub.3
    H     NH.sub.2        O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR253##     O     H   CH.sub.3
                                         OCH.sub.3
    H     N(CH.sub.2 CN).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     N(CH.sub.2 CH.sub.2 CN).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H     N(C.sub.2 H.sub.5).sub.2
                          O     H   CH.sub.3
                                         OCH.sub.3
    H
           ##STR254##     O     H   CH.sub.3
                                         OCH.sub.3
    ______________________________________


                                  TABLE VII-d
    __________________________________________________________________________
     ##STR255##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR256##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR257##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2C CC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR258##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR259##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR260##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR261##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR262##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR263##    O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR264##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR265##    O H  CH.sub.3
                               OCH.sub.3
                                   113-117.degree.
    __________________________________________________________________________


                                  TABLE VII-e
    __________________________________________________________________________
     ##STR266##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR267##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR268##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2CCC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR269##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR270##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR271##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR272##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR273##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR274##    O H  CH.sub.3
                               OCH.sub. 3
    H   N(CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR275##    O H  CH.sub.3
                               OCH.sub.3
    __________________________________________________________________________


                                  TABLE VII-f
    __________________________________________________________________________
     ##STR276##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR277##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR278##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2CCC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub. 4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR279##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR280##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR281##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR282##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR283##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR284##    O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub. 2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR285##    O H  CH.sub.3
                               OCH.sub.3
    __________________________________________________________________________


                                  TABLE VII-g
    __________________________________________________________________________
     ##STR286##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR287##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR288##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2CCC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR289##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR290##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR291##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR292##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR293##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR294##    O H  CH.sub.3
                               OCH.sub. 3
    H   N(CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR295##    O H  CH.sub.3
                               OCH.sub.3
    __________________________________________________________________________


                                  TABLE VII-h
    __________________________________________________________________________
     ##STR296##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR297##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR298##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2CCC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub. 3
    H   S(CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR299##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR300##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR301##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR302##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR303##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR304##    O H  CH.sub.3
                               OCH.sub. 3
    H   N(CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR305##    O H  CH.sub.3
                               OCH.sub.3
    __________________________________________________________________________


                                  TABLE VII-i
    __________________________________________________________________________
     ##STR306##
    A'  QR.sup.I       W R.sub.5
                            X  Y   m.p. (.degree.C.)
    __________________________________________________________________________
    H   SCH.sub.3      O H  CH.sub.3
                               OCH.sub.3
    H   SCH(CH.sub.3).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
         ##STR307##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR308##    O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCH.sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CHCHC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CCC.sub.2 H.sub.5
                       O H  CH.sub.3
                               OCH.sub.3
    H   S(CH.sub.2).sub.4 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H   SCH.sub.2 CN   O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.2 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-Cl
        S(CH.sub.2).sub.4 OCH.sub.3
                       O H  CH.sub.3
                               OCH.sub.3
    5-CH.sub.3
        SCH.sub.2 CHCHCH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    5-C.sub.2 H.sub.5
        SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR309##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR310##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR311##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR312##    O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR313##    O H  CH.sub.3
                               OCH.sub.3
    H   NH.sub.2       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR314##    O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(CH.sub.2 CH.sub.2 CN).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                       O H  CH.sub.3
                               OCH.sub.3
    H
         ##STR315##    O H  CH.sub.3
                               OCH.sub.3
    __________________________________________________________________________


              TABLE VII-j
    ______________________________________
     ##STR316##
                                                m.p.
    A'    QR.sup.I        W     R.sub.5
                                     X    Y     (.degree.C.)
    ______________________________________
    H     SCH.sub.3       O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH(CH.sub.3).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
           ##STR317##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR318##     O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCH.sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCHC.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2C CC.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     S(CH.sub.2).sub.4 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CN    O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.2 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.4 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-CH.sub.3
          SCH.sub.2 CHCHCH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-C.sub.2 H.sub.5
          SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR319##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR320##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR321##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR322##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR323##     O     H    CH.sub.3
                                          OCH.sub.3
    H     NH.sub.2        O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR324##     O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(C.sub.2 H.sub.5).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR325##     O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE VII-k
    ______________________________________
     ##STR326##
                                                m.p.
    A'    QR.sup.I        W     R.sub.5
                                     X    Y     (.degree.C.)
    ______________________________________
    H     SCH.sub.3       O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH(CH.sub.3).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
           ##STR327##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR328##     O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCH.sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCHC.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2CCC.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     S(CH.sub.2).sub.4 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CN    O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.2 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.4 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-CH.sub.3
          SCH.sub.2 CHCHCH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-C.sub.2 H.sub.5
          SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR329##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR330##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR331##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR332##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR333##     O     H    CH.sub.3
                                          OCH.sub.3
    H     NH.sub.2        O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR334##     O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(C.sub.2 H.sub.5).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR335##     O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE VII-l
    ______________________________________
     ##STR336##
                                                m.p.
    A'    QR.sup.I        W     R.sub.5
                                     X    Y     (.degree.C.)
    ______________________________________
    H     SCH.sub.3       O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH(CH.sub.3).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
           ##STR337##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR338##     O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCH.sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CHCHC.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2CC C.sub.2 H.sub.5
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     S(CH.sub.2).sub.4 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     SCH.sub.2 CN    O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.2 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-Cl  S(CH.sub.2).sub.4 OCH.sub.3
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-CH.sub.3
          SCH.sub.2 CHCHCH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    5-C.sub.2 H.sub.5
          SCH.sub.2 CCCH.sub.2 CH.sub.2 Cl
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR339##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR340##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR341##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR342##     O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR343##     O     H    CH.sub.3
                                          OCH.sub.3
    H     NH.sub.2        O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR344##     O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(CH.sub.2 CH.sub.2 CN).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H     N(C.sub.2 H.sub.5).sub.2
                          O     H    CH.sub.3
                                          OCH.sub.3
    H
           ##STR345##     O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE VIII-a
    ______________________________________
     ##STR346##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR347## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR348## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-b
    ______________________________________
     ##STR349##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR350## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR351## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-c
    ______________________________________
     ##STR352##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR353## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR354## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-d
    ______________________________________
     ##STR355##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR356## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR357## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-e
    ______________________________________
     ##STR358##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR359## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR360## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-f
    ______________________________________
     ##STR361##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR362## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR363## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-g
    ______________________________________
     ##STR364##
    A'   QR.sup.I    W      R.sub.5
                                 X.sub.1
                                       Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3   O      H    CH.sub.3
                                       CH.sub.3
    H    SCH.sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NH(CH.sub.2).sub.3 CH.sub.3
                     O      H    CH.sub.3
                                       CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.3
    H    N(CH.sub.3).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                     O      H    OCH.sub.3
                                       OCH.sub.3
          ##STR365## O      H    OCH.sub.3
                                       OCH.sub.3
    H
          ##STR366## O      H    OCH.sub.3
                                       OCH.sub.3
    ______________________________________


              TABLE VIII-h
    ______________________________________
     ##STR367##
    A'  QR.sup.I     W     R.sub.5
                               X.sub.1
                                      Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3    O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   S(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NH(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NHCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   N(CH.sub.3).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
         ##STR368##  O     H   OCH.sub. 3
                                      OCH.sub.3
    H
         ##STR369##  O     H   OCH.sub.3
                                      OCH.sub.3
    ______________________________________


              TABLE VIII-i
    ______________________________________
     ##STR370##
    A'  QR.sup.I     W     R.sub.5
                               X.sub.1
                                      Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3    O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   S(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NH(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NHCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   N(CH.sub.3).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
         ##STR371##  O     H   OCH.sub. 3
                                      OCH.sub.3
    H
         ##STR372##  O     H   OCH.sub.3
                                      OCH.sub.3
    ______________________________________


              TABLE VIII-j
    ______________________________________
     ##STR373##
    A'  QR.sup.I     W     R.sub.5
                               X.sub.1
                                      Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3    O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   S(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NH(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NHCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   N(CH.sub.3).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
         ##STR374##  O     H   OCH.sub.3
                                      OCH.sub.3
    H
         ##STR375##  O     H   OCH.sub.3
                                      OCH.sub.3
    ______________________________________


              TABLE VIII-k
    ______________________________________
     ##STR376##
    A'  QR.sup.I     W     R.sub.5
                               X.sub.1
                                      Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3    O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   S(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NH(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NHCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   N(CH.sub.3).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
         ##STR377##  O     H   OCH.sub. 3
                                      OCH.sub.3
    H
         ##STR378##  O     H   OCH.sub.3
                                      OCH.sub.3
    ______________________________________


              TABLE VIII-1
    ______________________________________
     ##STR379##
    A'  QR.sup.I     W     R.sub.5
                               X.sub.1
                                      Y.sub.1
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3    O     H   CH.sub.3
                                      CH.sub.3
    H   SCH.sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   S(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NH(CH.sub.2).sub.3 CH.sub.3
                     O     H   CH.sub.3
                                      CH.sub.3
    H   NHCH(CH.sub.3).sub.2
                     O     H   CH.sub.3
                                      CH.sub.3
    H   N(CH.sub.3).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
    H   N(C.sub.2 H.sub.5).sub.2
                     O     H   OCH.sub.3
                                      OCH.sub.3
         ##STR380##  O     H   OCH.sub.3
                                      OCH.sub. 3
    H
         ##STR381##  O     H   OCH.sub.3
                                      OCH.sub.3
    ______________________________________


              TABLE IX-a
    ______________________________________
     ##STR382##
    A'  QR.sup.I     W      R.sub.5
                                 Y.sub.1
                                       X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH.sub.3    O      H    CH.sub.3
                                       CH.sub.2
    H   SC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH.sub.2 CHCH.sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.5 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.8 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   N(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    ______________________________________


              TABLE IX-b
    ______________________________________
     ##STR383##
    A'  QR.sup.I     W      R.sub.5
                                 Y.sub.1
                                       X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH.sub.3    O      H    CH.sub.3
                                       CH.sub.2
    H   SC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH.sub.2 CHCH.sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.5 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.8 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   N(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    ______________________________________


              TABLE IX-c
    ______________________________________
     ##STR384##
    A'  QR.sup.I     W      R.sub.5
                                 Y.sub.1
                                       X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH.sub.3    O      H    CH.sub.3
                                       CH.sub.2
    H   SC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH.sub.2 CHCH.sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.5 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.8 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   N(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    ______________________________________


              TABLE IX-d
    ______________________________________
     ##STR385##
    A'  QR.sup.I     W      R.sub.5
                                 Y.sub.1
                                       X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH.sub.3    O      H    CH.sub.3
                                       CH.sub.2
    H   SC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH.sub.2 CHCH.sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.5 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.8 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   N(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    ______________________________________


              TABLE IX-e
    ______________________________________
     ##STR386##
    A'  QR.sup.I     W      R.sub.5
                                 Y.sub.1
                                       X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H   SCH.sub.3    O      H    CH.sub.3
                                       CH.sub.2
    H   SC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   SCH.sub.2 CHCH.sub.2
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHC.sub.2 H.sub.5
                     O      H    CH.sub.3
                                       CH.sub.2
    H   NHCH(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.5 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   NH(CH.sub.2).sub.8 CH.sub.3
                     O      H    CH.sub.3
                                       O
    H   N(CH.sub.3).sub.2
                     O      H    CH.sub.3
                                       O
    ______________________________________


              TABLE IX-f
    ______________________________________
     ##STR387##
    A'   QR.sup.I     W      R.sub.5
                                  Y.sub.1
                                        X.sub.11
                                             m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.2
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.2
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.2
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.2
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.2
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        O
    H    NH(CH.sub.2).sub.5 CH.sub.3
                      O      H    CH.sub.3
                                        O
    H    NH(CH.sub.2).sub.8 CH.sub.3
                      O      H    CH.sub.3
                                        O
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        O
    ______________________________________


              TABLE X-a
    ______________________________________
     ##STR388##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub.5 ).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE X-b
    ______________________________________
     ##STR389##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub.5 ).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE X-c
    ______________________________________
     ##STR390##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE X-d
    ______________________________________
     ##STR391##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub. 5).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE X-e
    ______________________________________
     ##STR392##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE X-f
    ______________________________________
     ##STR393##
    A'   QR.sup.I     W      R.sub.5
                                  X     Y    m.p. (.degree.C.)
    ______________________________________
    H    SCH.sub.3    O      H    CH.sub.3
                                        CH.sub.3
    H    SC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2).sub.3 CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    SCH.sub.2 CHCH.sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    S(CH.sub.2)CH.sub.3
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHCH(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    NHC.sub.2 H.sub.5
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(CH.sub.3).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    H    N(C.sub.2 H.sub.5).sub.2
                      O      H    CH.sub.3
                                        CH.sub.3
    ______________________________________


              TABLE XI-a
    ______________________________________
     ##STR394##
     A'
         ##STR395##       W     R.sub.5
                                     X     Y     (.degree.C.)m.p.
    ______________________________________
         ##STR396##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR397##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR398##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR399##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR400##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR401##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR402##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR403##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR404##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR405##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR406##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR407##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR408##      O     CH.sub.3
                                    CH.sub.3
                                          CH.sub.3
    H
         ##STR409##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR410##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR411##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR412##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR413##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR414##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR415##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR416##      O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR417##      O     H    OCH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-b
    ______________________________________
     ##STR418##
     A'
         ##STR419##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR420##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR421##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR422##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR423##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR424##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR425##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR426##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR427##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR428##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR429##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR430##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR431##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR432##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR433##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR434##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR435##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-c
    ______________________________________
     ##STR436##
     A'
         ##STR437##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR438##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR439##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR440##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR441##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR442##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR443##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR444##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR445##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR446##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR447##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR448##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR449##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR450##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR451##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR452##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR453##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-d
    ______________________________________
     ##STR454##
     A'
         ##STR455##        W     R .sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR456##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR457##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR458##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR459##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR460##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR461##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR462##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR463##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR464##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR465##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR466##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR467##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR468##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR469##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR470##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR471##       O     H    CH.sub.3
                                          OCH.sub.3
    H
         ##STR472##       O     H    CH.sub.3
                                          CH.sub.3
                                                155- 158.degree.
    ______________________________________


              TABLE XI-e
    ______________________________________
     ##STR473##
     A'
         ##STR474##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR475##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR476##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR477##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR478##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR479##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR480##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR481##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR482##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR483##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR484##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR485##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR486##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR487##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR488##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR489##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR490##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-f
    ______________________________________
     ##STR491##
     A'
         ##STR492##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR493##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR494##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR495##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR496##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR497##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR498##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR499##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR500##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR501##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR502##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR503##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR504##       O     CH.sub.3
                                     CH.sub. 3
                                          CH.sub.3
    H
         ##STR505##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR506##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR507##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR508##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-g
    ______________________________________
     ##STR509##
     A'
         ##STR510##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR511##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR512##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR513##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR514##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR515##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR516##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR517##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR518##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR519##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR520##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR521##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR522##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR523##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR524##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR525##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR526##       O     H    OCH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-h
    ______________________________________
     ##STR527##
     A'
         ##STR528##        W     R.sub.5
                                      X    Y      (.degree.
    ______________________________________
                                                C.)m.p.
         ##STR529##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR530##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR531##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR532##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR533##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR534##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR535##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR536##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR537##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR538##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR539##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR540##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR541##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR542##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR543##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR544##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-i
    ______________________________________
     ##STR545##
     A'
         ##STR546##        W     R.sub.5
                                      X    Y     m.p. (.degree.
    ______________________________________
                                                C.)
         ##STR547##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR548##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR549##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR550##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR551##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR552##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR553##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR554##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR555##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR556##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR557##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR558##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR559##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR560##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR561##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR562##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-j
    ______________________________________
     ##STR563##
     A'
         ##STR564##        W     R.sub.5
                                      X    Y     m.p. (.degree.
    ______________________________________
                                                C.)
         ##STR565##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR566##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR567##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR568##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR569##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR570##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR571##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR572##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR573##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR574##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR575##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR576##       O     CH.sub.3
                                     CH.sub. 3
                                          CH.sub.3
    H
         ##STR577##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR578##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR579##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR580##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-k
    ______________________________________
     ##STR581##
     A'
         ##STR582##        W     R.sub.5
                                      X    Y     m.p. (.degree.
    ______________________________________
                                                C.)
         ##STR583##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR584##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR585##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR586##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR587##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR588##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR589##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR590##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR591##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR592##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR593##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR594##       O     CH.sub.3
                                     CH.sub. 3
                                          CH.sub.3
    H
         ##STR595##       O     CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR596##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR597##       O     H    CH.sub.3
                                          CH.sub.3
    H
         ##STR598##       O     H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XI-1
    ______________________________________
     ##STR599##
     A'
         ##STR600##       W      R.sub.5
                                      X    Y     m.p. (.degree.C.)
    ______________________________________
         ##STR601##      O      H    CH.sub.3
                                          CH.sub.3
    H
         ##STR602##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR603##      O      H    CH.sub.3
                                          CH.sub.3
    H
         ##STR604##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR605##      O      H    CH.sub.3
                                          CH.sub.3
    H
         ##STR606##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR607##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR608##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR609##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR610##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR611##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR612##      O      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR613##      0      CH.sub.3
                                     CH.sub.3
                                          CH.sub.3
    H
         ##STR614##      O      H    CH.sub.3
                                          CH.sub.3
    H
         ##STR615##      O      H    CH.sub.3
                                          CH.sub.3
    H
         ##STR616##      O      H    CH.sub.3
                                          OCH.sub.3
    ______________________________________


              TABLE XII
    ______________________________________
    Other compounds within the scope of this
    invention include:
    ______________________________________
     ##STR617##
     ##STR618##
     ##STR619##
     ##STR620##
     ##STR621##
     ##STR622##
     ##STR623##
     ##STR624##
     ##STR625##
     ##STR626##
     ##STR627##
     ##STR628##
     ##STR629##
     ##STR630##
     ##STR631##
     ##STR632##
     ##STR633##
    ______________________________________


              TABLE XII-a
    ______________________________________
     ##STR634##
    A'          W'    W       R.sup.I
    ______________________________________
    H           S     O       C.sub.2 H.sub.5
    H           S     O       CH(CH.sub.3).sub.2
    H           S     O       CH.sub.2 CH.sub.2 Cl
    H           S     O       (CH.sub.2).sub.6 H
    H           S     O
                               ##STR635##
    H           S     O       CH.sub.2CHCH.sub.2
    H           S     O       CH.sub.2CHCHCH.sub.3
    H           S     O       CH.sub.2 CHCHCH.sub.2 CH.sub.3
    H           S     O
                               ##STR636##
    H           S     O       CH.sub.2 CH(CH.sub.3).sub.2
    H           S     O       CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2
    H           S     O       CH.sub.2 CH.sub.2 Cl
    H           S     O       CH.sub.2 CH(CH.sub.2 Cl).sub.2
    H           S     O       CH.sub.2 CCl.sub.3
    H           S     O       (CH.sub.2).sub.6 Cl
    H           S     O       (CH.sub.2).sub.6 Br
    H           S     O       CH.sub. 2 CH.sub.2 Br
    H           S     O       (CH.sub.2).sub.6 F
    H           S     O       (CH.sub.2).sub.4 F
    H           S     O       CH.sub.2 CN
    H           S     O       CH.sub.2 CH.sub.2 CN
    H           S     O       CH.sub.2 CH.sub.2 OCH.sub.3
    H           S     O       (CH.sub.2).sub.6 OCH.sub.3
    H           S     O       (CH.sub.2).sub.3 OCH.sub.3
    H           S     O
                               ##STR637##
    H           S     O
                               ##STR638##
    H           S     O
                               ##STR639##
    H           S     O
                               ##STR640##
    H           S     O       CH.sub.2 CN
    H           S     O
                               ##STR641##
    H           S     O
                               ##STR642##
    H           S     O
                               ##STR643##
    H           S     O
                               ##STR644##
    H           S     O
                               ##STR645##
    H           S     O
                               ##STR646##
    H           S     O
                               ##STR647##
    H           S     O
                               ##STR648##
    H           S     O       CH.sub.2 OCH.sub.3
    H           S     O       CH.sub.2 OC.sub.2 H.sub.5
    H           S     O       CH.sub.2 O(CH.sub.2).sub.4 H
    H           S     O       CH.sub.2 CHCHCl
    H           S     O       CH.sub.2 CHCHCH.sub.2 Cl
    H           S     O       CH.sub.2 CHCH(CH.sub.2).sub.3 Cl
    H           S     O       CH.sub.2 CCCH.sub.3
    H           S     O       CH.sub.2 CCCH.sub.2 Cl
    H           S     O       CH.sub.2 CCCH.sub.2 CH.sub.2Cl
    H           S     O
                               ##STR649##
    H           S     O
                               ##STR650##
    H           S     O
                               ##STR651##
    H           S     O
                               ##STR652##
    H           S     O
                               ##STR653##
    H           S     O
                               ##STR654##
    H           S     O
                               ##STR655##
    H           S     O
                               ##STR656##
    H           S     O
                               ##STR657##
    H           S     O
                               ##STR658##
    H           S     O
                               ##STR659##
    H           S     O
                               ##STR660##
    H           S     O
                               ##STR661##
    H           S     O
                               ##STR662##
    H           S     O
                               ##STR663##
    H           S     O       CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub. 3
    H           S     O       CH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2
    H           S     O
                               ##STR664##
    H           S     O       CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl
    H           S     O       CH.sub.2 CH.sub.2 OCH.sub.2 CCl.sub.3
    H           S     O
                               ##STR665##
    H           S     O
                               ##STR666##
    H           S     O       (CH.sub.2).sub.3 OCH(CH.sub.3).sub.2
    H           S     O       (CH.sub.2).sub.3 OCH.sub.2 CH.sub.3
    H           S     O       CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3
    H           S     O       CH.sub.2 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.2
                              OC.sub.2 H.sub.5
    5-CH.sub.3  S     O       CH.sub.3
    H           O     O       CH.sub.3
    H           S     S       CH.sub.3
    4-CH.sub.3  S     O       CH.sub.3
    4-Cl        S     O       CH.sub.3
    4-Br        S     O       CH.sub.3
    5-Br        S     O       CH.sub.3
    4-NO.sub.2  S     O       CH.sub.3
    4-C.sub.2 H.sub.5
                S     O       CH.sub.3
    5-C.sub.2 H.sub.5
                S     O       CH.sub.3
    5-n-C.sub.7 H.sub. 9
                S     O       CH.sub.3
    5-CH(CH.sub.3).sub.2
                S     O       CH.sub.3
    4-CF.sub.3  S     O       CH.sub.3
    5-OCH.sub.3 S     O       CH.sub.3
    ______________________________________


              TABLE XII-b
    ______________________________________
     ##STR667##
    A'          W'     W      R.sup.I
    ______________________________________
    H           S      O      C.sub.2 H.sub.5
    H           S      O      CH(CH.sub.3).sub.2
    H           S      O      CH.sub.2 CH.sub.2 Cl
    H           S      O      (CH.sub.2).sub.6 H
    H           S      O
                               ##STR668##
    H           S      O      CH.sub.2CHCH.sub.2
    H           S      O      CH.sub.2CHCHCH.sub.3
    H           S      O      CH.sub.2 CHCHCH.sub.2 CH.sub.3
    H           S      O
                               ##STR669##
    H           S      O      CH.sub.2 CH(CH.sub.3).sub.2
    H           S      O      CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2
    H           S      O      CH.sub.2 CH.sub.2 Cl
    H           S      O      CH.sub.2 CH(CH.sub.2 Cl).sub.2
    H           S      O      CH.sub.2 CCl.sub.3
    H           S      O      (CH.sub.2).sub.6 Cl
    H           S      O      (CH.sub.2).sub.6 Br
    H           S      O      CH.sub.2 CH.sub.2 Br
    H           S      O      (CH.sub.2).sub.6 F
    H           S      O      (CH.sub.2).sub.4 F
    H           S      O      CH.sub.2 CN
    H           S      O      CH.sub.2 CH.sub.2 CN
    H           S      O      CH.sub.2 CH.sub.2 OCH.sub.3
    H           S      O      (CH.sub.2).sub.6 OCH.sub.3
    H           S      O      (CH.sub.2).sub.3 OCH.sub.3
    H           S      O
                               ##STR670##
    H           S      O
                               ##STR671##
    H           S      O
                               ##STR672##
    H           S      O
                               ##STR673##
    H           S      O      CH.sub.2 CN
    H           S      O
                               ##STR674##
    H           S      O
                               ##STR675##
    H           S      O
                               ##STR676##
    H           S      O
                               ##STR677##
    H           S      O
                               ##STR678##
    H           S      O
                               ##STR679##
    H           S      O
                               ##STR680##
    H           S      O
                               ##STR681##
    H           S      O      CH.sub.2 OCH.sub.3
    H           S      O      CH.sub.2 OC.sub.2 H.sub.5
    H           S      O      CH.sub.2 O(CH.sub.2).sub.4 H
    H           S      O      CH.sub.2 CHCHCl
    H           S      O      CH.sub.2 CHCHCH.sub.2 Cl
    H           S      O      CH.sub.2 CHCH(CH.sub.2).sub.3 Cl
    H           S      O      CH.sub.2 CCCH.sub.3
    H           S      O      CH.sub.2 CCCH.sub.2 Cl
    H           S      O      CH.sub.2 CCCH.sub.2 CH.sub.2Cl
    H           S      O
                               ##STR682##
    H           S      O
                               ##STR683##
    H           S      O
                               ##STR684##
    H           S      O
                               ##STR685##
    H           S      O
                               ##STR686##
    H           S      O
                               ##STR687##
    H           S      O
                               ##STR688##
    H           S      O
                               ##STR689##
    H           S      O
                               ##STR690##
    H           S      O
                               ##STR691##
    H           S      O
                               ##STR692##
    H           S      O
                               ##STR693##
    H           S      O
                               ##STR694##
    H           S      O
                               ##STR695##
    H           S      O
                               ##STR696##
    H           S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3
    H           S      O      CH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2
    H           S      O
                               ##STR697##
    H           S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl
    H           S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CCl.sub.3
    H           S      O
                               ##STR698##
    H           S      O
                               ##STR699##
    H           S      O      (CH.sub.2).sub.3 OCH(CH.sub.3).sub.2
    H           S      O      (CH.sub.2).sub.3 OCH.sub.2 CH.sub.3
    H           S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3
    H           S      O      CH.sub.2 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.2
                              OC.sub.2 H.sub.5
    5-CH.sub.3  S      O      CH.sub.3
    H           O      O      CH.sub.3
    H           S      S      CH.sub.3
    2-CH.sub.3  S      O      CH.sub.3
    2-Cl        S      O      CH.sub.3
    2-Br        S      O      CH.sub.3
    5-Br        S      O      CH.sub.3
    2-NO.sub.2  S      O      CH.sub.3
    2-C.sub.2 H.sub.5
                S      O      CH.sub.3
    5-C.sub.2 H.sub.5
                S      O      CH.sub.3
    5-n-C.sub.7 H.sub.9
                S      O      CH.sub.3
    5-CH(CH.sub.3).sub. 2
                S      O      CH.sub.3
    2-CF.sub.3  S      O      CH.sub.3
    5-OCH.sub.3 S      O      CH.sub.3
    ______________________________________


              TABLE XII-c
    ______________________________________
     ##STR700##
    A'         W'     W      R.sup.I
    ______________________________________
    H          S      O      C.sub.2 H.sub.5
    H          S      O      CH(CH.sub.3).sub.2
    H          S      O      CH.sub.2 CH.sub.2 Cl
    H          S      O      (CH.sub.2).sub.6 H
    H          S      O
                              ##STR701##
    H          S      O      CH.sub.2CHCH.sub.2
    H          S      O      CH.sub.2CHCHCH.sub.3
    H          S      O      CH.sub.2 CHCHCH.sub.2 CH.sub.3
    H          S      O
                              ##STR702##
    H          S      O      CH.sub.2 CH(CH.sub.3).sub.2
    H          S      O      CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2
    H          S      O      CH.sub.2 CH.sub.2 Cl
    H          S      O      CH.sub.2 CH(CH.sub.2 Cl).sub.2
    H          S      O      CH.sub.2 CCl.sub.3
    H          S      O      (CH.sub.2).sub.6 Cl
    H          S      O      (CH.sub.2).sub.6 Br
    H          S      O      CH.sub.2 CH.sub.2 Br
    H          S      O      (CH.sub.2).sub.6 F
    H          S      O      (CH.sub.2).sub.4 F
    H          S      O      CH.sub.2 CN
    H          S      O      CH.sub.2 CH.sub.2 CN
    H          S      O      CH.sub.2 CH.sub.2 OCH.sub.3
    H          S      O      (CH.sub.2).sub.6 OCH.sub.3
    H          S      O      (CH.sub.2).sub.3 OCH.sub.3
    H          S      O
                              ##STR703##
    H          S      O
                              ##STR704##
    H          S      O
                              ##STR705##
    H          S      O
                              ##STR706##
    H          S      O      CH.sub.2 CN
    H          S      O
                              ##STR707##
    H          S      O
                              ##STR708##
    H          S      O
                              ##STR709##
    H          S      O
                              ##STR710##
    H          S      O
                              ##STR711##
    H          S      O
                              ##STR712##
    H          S      O
                              ##STR713##
    H          S      O
                              ##STR714##
    H          S      O      CH.sub.2 OCH.sub.3
    H          S      O      CH.sub.2 OC.sub.2 H.sub.5
    H          S      O      CH.sub.2 O(CH.sub.2).sub.4 H
    H          S      O      CH.sub.2 CHCHCl
    H          S      O      CH.sub.2 CHCHCH.sub.2 Cl
    H          S      O      CH.sub.2 CHCH(CH.sub.2).sub.3 Cl
    H          S      O      CH.sub.2 CCCH.sub.3
    H          S      O      CH.sub.2 CCCH.sub.2 Cl
    H          S      O      CH.sub.2 CCCH.sub.2 CH.sub.2Cl
    H          S      O
                              ##STR715##
    H          S      O
                              ##STR716##
    H          S      O
                              ##STR717##
    H          S      O
                              ##STR718##
    H          S      O
                              ##STR719##
    H          S      O
                              ##STR720##
    H          S      O
                              ##STR721##
    H          S      O
                              ##STR722##
    H          S      O
                              ##STR723##
    H          S      O
                              ##STR724##
    H          S      O
                              ##STR725##
    H          S      O
                              ##STR726##
    H          S      O
                              ##STR727##
    H          S      O
                              ##STR728##
    H          S      O
                              ##STR729##
    H          S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.3
    H          S      O      CH.sub.2 CH.sub.2 OCH(CH.sub.3).sub.2
    H          S      O
                              ##STR730##
    H          S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 Cl
    H          S      O      CH.sub.2 CH.sub.2 OCH.sub.2 OCl.sub.3
    H          S      O
                              ##STR731##
    H          S      O
                              ##STR732##
    H          S      O      (CH.sub.2).sub.3 OCH(CH.sub.3).sub.2
    H          S      O      (CH.sub.2).sub.3 OCH.sub.2 CH.sub.3
    H          S      O      CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3
    H          S      O      CH.sub.2 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.2
                             OC.sub.2 H.sub.5
    5-CH.sub.3 S      O      CH.sub.3
    H          O      O      CH.sub.3
    H          S      S      CH.sub.3
    4-CH.sub.3 S      O      CH.sub.3
    4-Cl       S      O      CH.sub.3
    4-Br       S      O      CH.sub.3
    5-Br       S      O      CH.sub.3
    4-NO.sub.2 S      O      CH.sub.3
    4-C.sub.2 H.sub.5
               S      O      CH.sub.3
    5-C.sub.2 H.sub.5
               S      O      CH.sub.3
    5-n-C.sub.7 H.sub.9
               S      O      CH.sub.3
    5-CH(CH.sub.3).sub. 2
               S      O      CH.sub.3
    4-CF.sub.3 S      O      CH.sub.3
    5-OCH.sub.3
               S      O      CH.sub.3
    ______________________________________


              TABLE XII-d
    ______________________________________
     ##STR733##
    X              Y           m.p. (.degree.C.)
    ______________________________________
    CH.sub.3       OCH.sub.3   182-187(d)
    OCH.sub.3      OCH.sub.3   195-197
    ______________________________________

                  TABLE XVIII
    ______________________________________
                Active  Weight Percent*
                Ingred-           Surfac-
                ient    Diluent(s)
                                  tant(s)
    ______________________________________
    Wettable Powders
                  20-90      0-74     1-10
    Oil Suspensions,
                   3-50     40-95     0-15
    Emulsions, Solu-
    tions (including
    Emulsifiable
    Concentrates)
    Aqueous Suspension
                  10-50     40-84     1-20
    Dusts          1-25     70-99     0-5
    Granules and  0.1-95      5-99.9  0-15
    Pellets
    High Strength 90-99      0-10     0-2
    Compositions
    ______________________________________
     *Active ingredient plus at least one of a Surfactant or a Diluent equals
     100 weight percent.

    ______________________________________
    Wettable Powder
    ______________________________________
    methyl 3-[[(4,6-dimethylpyrimidin-2-yl)aminocarbonyl]-
                                80%
    aminosulfonyl]-2-thiophenecarboxylate
    sodium alkylnaphthalenesulfonate
                                2%
    sodium ligninsulfonate      2%
    synthetic amorphous silica  3%
    kaolinite                   13%
    ______________________________________

    ______________________________________
    Wettable Powder
    ______________________________________
    methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)-
                             50%
    aminocarbonyl]aminosulfonyl]-2-thiophene-
    carboxylate
    sodium alkylnaphthalenesulfonate
                              2%
    low viscosity methyl cellulose
                              2%
    diatomaceous earth       46%
    ______________________________________

    ______________________________________
    Granule
    ______________________________________
    wettable powder of Example 8
                            5%
    attapulgite granules   95%
    (U.S.S. 20-40 mesh; 0.84-0.42 mm)
    ______________________________________

    ______________________________________
    Extruded Pellet
    ______________________________________
    methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-
                                 25%
    aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate
    anhydrous sodium sulfate     10%
    crude calcium ligninsulfonate
                                  5%
    sodium alkylnaphthalenesulfonate
                                  1%
    calcium/magnesium bentonite  59%
    ______________________________________

    ______________________________________
    Oil Suspension
    ______________________________________
    methyl 3-[[(4,6-dimethylpyrimidin-2-yl)amino-
                               25%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    polyoxyethylene sorbitol hexaoleate
                                5%
    highly aliphatic hydrocarbon oil
                               70%
    ______________________________________

    ______________________________________
    Wettable Powder
    ______________________________________
    methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)amino-
                               20%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    sodium alkylnaphthalenesulfonate
                               4%
    sodium ligninsulfonate     4%
    low viscosity methyl cellulose
                               3%
    attapulgite                69%
    ______________________________________

    ______________________________________
    Oil Suspension
    ______________________________________
    methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-
                                 35%
    aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate
    blend of polyalcohol carboxylic
                                  6%
    esters and oil soluble petroleum
    sulfonates
    xylene                       59%
    ______________________________________

    ______________________________________
    High Strength Concentrate
    ______________________________________
    methyl 3-[[(4,6-dimethylpyrimidin-2-yl)amino-
                                99%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    silica aerogel             0.5%
    synthetic amorphous silica 0.5%
    ______________________________________

    ______________________________________
    Low Strength Granule
    ______________________________________
    methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)amino-
                               1%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    N,N--dimethylformamide     9%
    attapulgite granules       90%
    (U.S.S. 20-40 mesh)
    ______________________________________

    ______________________________________
    Aqueous Suspension
    ______________________________________
    methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-
                                 40%
    aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate
    polyacrylic acid thickener  0.3%
    dodecylphenol polyethylene glycol ether
                                0.5%
    disodium phosphate            1%
    monosodium phosphate        0.5%
    polyvinyl alcohol           1.0%
    water                       56.7%
    ______________________________________

    ______________________________________
    Solution
    ______________________________________
    methyl 3-[[(4,6-dimethylpyrimidin-2-yl)amino-
                                5%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    water                      95%
    ______________________________________

    ______________________________________
    Granule
    ______________________________________
    methyl 3-[[(4,6-dimethoxypyrimidin-2-yl)amino-
                               80%
    carbonyl]aminosulfonyl]-2-thiophenecarboxylate
    wetting agent               1%
    crude ligninsulfonate salt (containing
                               10%
    5-20% of the natural sugars)
    attapulgite clay            9%
    ______________________________________

    ______________________________________
    Low Strength Granule
    ______________________________________
    methyl 3-[[(4-methoxy-6-methylpyrimidin-2-yl)-
                                 0.1%
    aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylate
    attapulgite granules        99.9%
    (U.S.S. 20-40 mesh)
    ______________________________________

    TABLE A
         MORN-     BARN-        BUSH- COT- ING- COCKLE-  NUT- CRAB- YARD-
     WILD   SOY-  SOR- kg/ha BEAN TON GLORY BUR CASSIA SEDGE GRASS GRASS OATS
     WHEAT CORN BEAN RICE GHUM
       POST-EMERGENCE
      ##STR734##
      0.1 6C,9G,6Y 3U,9G 9C 5C,9G 0 5C,9G 5C,9G 6C,9G 2G 1C,9G 1C,9H 3G 2C,9G
     1C,9G
      ##STR735##
      0.1 5C,8G,6Y 7C,9G 10C 9C 2C 1C,9G 3C,8G 9C 1C,7G 2C,8G 2U,9G 5C,9G
     5C,9G 5U,9G
      ##STR736##
      0.1 8D,9G,6Y 7C,9G 10C 3C,9G 1C,3G 4C,9G 6C,9G 9C 2C,8G 3C,7G 1C,9G
     2C,8G 3C,9G 3C,9G
      ##STR737##
      0.1 9C 3C,7G 5C,8G 10C 1C 0 1C,5G 2C,8H 0 0 2C,8H 1C,2H -- 1C,9G
      ##STR738##
      0.4 6C,9G 3C,3H 1C,3H 1C,5G 2C,2H 1C 4G 2C,5H 0 0 2C,7H 2C,3G 1C,5G
     2C,9H
      ##STR739##
      0.1 2C,8G,6Y 9C 10C 10C 2C,7H 1C 1C 2C,9H 1H 1H 9H 5C,9G 2C,8G 2C,7H
      ##STR740##
      0.1 9C 9C 10C 6C 1C 1C 3C 10C 0 0 7C 2C 5C 9G
      ##STR741##
      0.4 3C,4G,6F 1C,7G 10C 10C 0 5C,5G 10C 10C 2C,3G 3C,5G 3U,5G 4G 3C,4G
     3C,4G
      ##STR742##
      0.05 3C 4C,8G 4C,9H 2C,9G 2C 0 0 1C 1C 2C 1C,2G 1H 1C,2G 1C,5H
      ##STR743##
      0.05 6Y,7C,9G 6C,9G 10C 6C,9G 1C,4G 2C,8G 2C 3C,7H 2C 2C,9G 2C,8H 2C,8G
     2C,9G 2C,9H
      ##STR744##
      0.05 2B 0 1C,3G 1C 1C 0 0 0 0 0 0 1H 5G 2C,8H
      ##STR745##
      0.05 1B 3G 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR746##
      0.05 6Y,1B,2H 4C,9G 3C,9G 3C,9H 2C 2C,5G 1C 2C,6H 0 0 2C,8H 2C,9G 1C,3G
     1C,9G
      ##STR747##
      0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR748##
      0.05 3D,6Y 0 0 0 0 2G 0 2G 0 0 2C,7H 1H 8G 2C,9G
      ##STR749##
      0.4 9C 10C 10C 10C 9C 7C,9G 9C 9C 9C 9C 7U,9C 9C 8C 9C
      ##STR750##
      0.4 9C 9C 10C 10C 9C 9C 9C 9C 9C 9C 10C 9C 8C 9C
      ##STR751##
      0.4 9C 9C 10C 9C 9C 6C,9G 9C 9C 8C 4C,8G 5U,10C 6C,9G 5C,9G 6C,9G
      ##STR752##
      0.4 9C 9C 10C 9C 9C 9C 8C 9C 2C,8G 1C,5G 8U,9C 5C,9G 9C 2C,9G
      ##STR753##
      0.1 9C 9C 10C 10C 2C 1C 1C 3C 0 0 3C 9C 5C 2C
      ##STR754##
      0.05 7C,9G,6Y 6C,9G 10C 5C,9G 1C 9G 5G 4C,9H 2G 1C,6G 5C,9G 6H 8G 6C,9G
      ##STR755##
      0.04 9C 9C 10C 9C 9C 9C 9C 9C 9C 9C 6U,9C 9C 6C,9G 9C
      ##STR756##
      0.4 9C 9C 10C 9C 6C,9G 9C 9C 9C 9C 8C 5U,9C 9C 6C,9G 9C
      ##STR757##
      0.1 9C 9C 9C 3C 1C 2C 1C 9C 2C 1C 5C 9C 9C 5C
      ##STR758##
      1.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR759##
      2.0 6C,9G,6Y 6C,9G 6C,9G 3C,9G 2C,7G 6C,7G 9C 10C 9C 9C 7U,9C 6C,9G
     4C,9G 9C
      ##STR760##
      0.05 2G,4G,6Y 3C,3H,7G 9C 3C,9G 1C 2C,5G,5X 3G 3C,8H 2C 1C,2G 2C,8G
     2H,9G,5X 8G 2H,9G
      ##STR761##
      0.05 3C,7G,6Y 3C,4H,9G 3C,9G 2C,9G 1C 2C,7G 1C 3C,9H 1C 1C 9H 2C,8G
     8G,5T 9G,5I
      ##STR762##
      0.05 3C,8G,6Y 4C,3H,9G 9C 9C 1C 2C,7G 1C,5G 9C 1C 1C,2G 3H,9G 3H,9G,5X
     9C 5C,9G
      ##STR763##
      0.05 1C 2C 1C 0 0 0 0 0 0 0 0 0 0 0
      ##STR764##
      0.05 5C,9G,6Y 5C,9G 4C,8G 10C 1C,3H 2C,9G 1C 2C,9H 0 0 1C 2C,9G 2C,8G
     2C,9H
      ##STR765##
      0.05 5C,9G,6Y 5C,9G 6C,9G 5C,9G 2C,4G 2C,9G 7G 9C 1C,6G 1C,6G 1C,4G
     2C,2H,8G 5C,9G 4C,9G
      ##STR766##
      0.05 2C,9G,6Y 5C,9G 5C,9G 2H,9G 1C,5G 8G 2C,6G 2C,7H 0 0 1C,3G 0 6G
     2C,9H
      ##STR767##
      0.05 1C,4G 2C,2H,8G 1C,5G 2G 1C,2G 1C,8G 1C,5G 1C,6G 0 1G 1C,2G 1H 8G
     7H
      ##STR768##
      0.05 5C,9G,6Y 4C,7G 2C,7G 2C,9G 1C 4C,9G 9G 5C,9H 0 2C,9G 2C,9H 0 9G
     1C,9G
      ##STR769##
      20.05 1C,1H0 00 00 00 00 00 4G0 6H0 00 00 00 1C0 00 2G0
      ##STR770##
      0.05 3C,5G,6Y 5C,9G 10C 5C,9G 2C,6G 9C 3C 2C,9H 0 2C 2C,7H 1C,5H 2C,8G
     9H
      ##STR771##
      0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR772##
      0.05 2H 2C,7G 1C 5G 1C 2C,8G 0 3C,9H 0 0 2G 0 5G 9G
      ##STR773##
      2.0 2C 2C 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR774##
      0.4 5S,7G,6Y 5C,9G 3C,8G 5C,9G 0 5G 2C,6G 5C,9H 0 0 2C,6H 0 1C,7G 1C,5H
      ##STR775##
      0.1 0 2G,2C,3H 5G,2C 8G 0 0 0 0 0 0 0 0 0 0
      ##STR776##
      0.1 10G,8C 10G,7C 10G,3C 10G 7G 0 0 3G 0 0 3G 10G,4C 10G,3C 9G
      ##STR777##
      0.1 10G,8C 10G,8C 10C 10C 9G 7G 0 5G 2G 2G 4G 10G,4H 1C,9G 7G
      ##STR778##
      0.05 10G,3H,2C 9G,4H,3C 10G,3C 10G,3H,2C 3G 9G,1C 4G 9G,5H 4G 6G
     9G,2U,2C 9G 10G,2C 10G
      ##STR779##
      0.05 9C 10C 9C 10C 1C 9C 9G 6C 1C 1C 3U 6C 5C 10C
      ##STR780##
      0.05 9C 9C 3C,9G 9C 1C,3G 9C 5C,9G 9C 3G 3C,9G 4U,9C 3C,9H 5C,9G 5U,9G
      ##STR781##
      0.05 3C,9G,6Y 5C,9G 2C,9G 9C 1C,3G 3G 2G 2C,9H 0 0 1U,9G 3H,8H 2C,9G
     1U,9G
      ##STR782##
      0.05 9C 10C 9C 10C 2C 1C 2G 2C 0 0 2C 3C 2C 2C
      ##STR783##
      0.4 0 5C,8G 4C,9G 2H,7G 2C 0 2G 1H 0 0 2G 1G 3G 2G
      ##STR784##
      0.05 5G,6Y 3C,5H,9G 2C,8G 6G 1C,4G 3G 2G 2C,6H 0 0 5H 0 3C,9G 2C,9G
      ##STR785##
      0.05 3C,9G,6Y 6C,9G 2C,9G 10C 1C,3G 2C,8G 4G 2C,9H 1C 1C 2C,8H 2C,6H 7G
     2C,9G
      ##STR786##
      0.05 5C,9G,6Y 5C,9G 9C 2C,9G 1C,3G 2G 2G 5H 0 0 2G 2H,6G 6G 1H,7G
      ##STR787##
      0.05 5C,9G,6Y 6C,9G 6C,9G 6C,9G 1C,3G 2G 0 1H 0 0 2G 7H 5G 5G
      ##STR788##
      0.05 3C,8G,6Y 5C,9G 3C,9G 7G 1C 0 0 7H 0 0 0 0 0 6H
      ##STR789##
      0.05 3C,6Y -- 2C,9G 1C 1C 9G 6G 9H 0 2G 2C,8H 1C,2G 7G 9G
      ##STR790##
      0.05 2G,6F -- 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR791##
      0.05 2C,5G,6Y 2C,3H,8G 2C 1C 1C,3G 5G 6G 3C,9H 0 0 1C 1C,3G 1C,7G 5C,9H
      ##STR792##
      0.05 0 -- 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR793##
      0.05 2C,7G,6Y 5C,8G 4C,8G 3G 2C 5G 6G 5C,9H 4G 3G 3G 2C,2H 4C,9G 3C,9H
      ##STR794##
      0.05 0 -- 2C 0 1C 0 2H 1C 0 0 0 1H 0 1C
      ##STR795##
      0.05 3C,7G,6Y -- 2C,7G 2C,7H 1C 2C,7G 3C,8H 2C,9H 0 9G 2C,9H 2C 3C,9G
     1C,9G
      ##STR796##
      0.1 1C,6Y 0 1C 2G 0 0 0 3H 0 0 0 0 0 2C,7G
      ##STR797##
      0.4 6C,9G,6Y 6C,9G 10C 10C 2C,5G 8G 9C 9C 4C,9G 4C,9G 5U,9G 2C,2H,8G
     6C,9G 5U,9G
      ##STR798##
      0.05 2C,8G,6Y 3C,7G 2C,7G 2C,8G 1C 2G 0 0 0 0 3H 0 2C 2C,9H
      ##STR799##
      0.05 9C 9C 9C 9C 2C 9C 9C 10C 5C 9C 8U 10C 6C 5C
      ##STR800##
      0.05 9C 6C,9G 6C,9G 9C 3C,9G 5C,8G 5C,8G 10C 5C,9G 9C 7U,10C 6C,9G
     5C,9G 10C
      ##STR801##
      0.05 9C 5C,9G 9C 9C 2C,3H 2C,7G 6G 6C,9H 0 0 7U,9H 9C 2C,7G 2C,9G
      ##STR802##
      2.0 4S,7G,6Y -- 0 0 0 0 0 0 0 0 0 00 0
      ##STR803##
      2.0 5S,9G,6Y -- 1C 0 0 0 2C 2C,5H 0 0 1C,4H 3G 2H
      ##STR804##
      2.0 5S,8G,6Y -- 2C,5G 2C,8H 2C 0 3G 1H 0 2H 2C,8G 4G 2G
       PRE-EMERGENCE
      ##STR805##
      0.1 9G 9G 6G 10E 1C,7G 1C,9H 1C,6G 1C,9G 1C,9H 0 10E 10H
      ##STR806##
      0.1 9G 9H 8G 10E 1C,7G 1C,9H 1C,8G 1C,9G 9G 6H 10E 10E
      ##STR807##
      0.1 9G 9H 8G 10E 1C,8G 1C,9H 1C,8G 1C,9H 9G 6H 10E 1C,9H
      ##STR808##
      0.1 9G 8H 2C 0 0 1C,5G 0 0 1C,4G 0 10E 1C,9H
      ##STR809##
      0.4 5G 9G 2G 10E 3C 3C 0 0 1C,5H 1C,1H 10E 3C,9H
      ##STR810##
      0.1 9H 9H 6G 7G 5G 2C,7G 0 0 5G 2C,5H 10E 1C,7H
      ##STR811##
      0.1 9G 8H 8G 3G 2C 2C,8G 0 3G 1C,8G 2C,4G 9H 1C,9H
      ##STR812##
      0.4 5G,3C 6C,5G 4G 10E 4C,7G 5C,8G 3C,4G 10E  1C,3G 10E 7C,8G
      ##STR813##
      0.05 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR814##
      0.05 9H 9H 5G 10E 1C 9H,3C 2C,7G 9G 1C,9H 1C,3H 4C,9H 2C,8H
      ##STR815##
      0.05 0 9H 2C 0 0 1C  0 1C,5G 0 2C 6H
      ##STR816##
      0.05 0 9H 0 0 0 0 0 0 0 0 0 0
      ##STR817##
      0.05 9G 5G 0 0 0 5H 0 0 1C,5C 2C,4H 1C,6G 2C
      ##STR818##
      0.05 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR819##
      0.05 0 3C,8H 1H 0 0 1H 0 0 2G 3H 5G 6H
      ##STR820##
      0.4 9H 9H 10C 10E 10E 9H 5C,9H 10E 10E 9H 10E 10E
      ##STR821##
      0.4 9H 9H 9H 10E 10E 5C,9H 5C,9H 10E 10E 9H 10E 10E
      ##STR822##
      0.4 9G 9H 9G 9G 6C,9G 5C,9H 3C,9G 3C,9G 10E 9H 10E 6C,9H
      ##STR823##
      0.4 9H 9H 3C,9G 10E 3C,9H 5C,9H 3C,9G 1C,8H 3C,9H 9H 10E 6C,9H
      ##STR824##
      0.1 9G 9H 6G 10E 2G 3C,9H 2C,7G 1C,3G 3C,9G 9H 9H 4C,9G
      ##STR825##
      0.05 9G 9H 8G 10E 1C 2C,9H 1C,8G 1C,9G 1C,9G 1C,3G 10E 3C,9G
      ##STR826##
      0.04 9G 9H 6C,9G 10E 10E 3C,9H 2C,9H 10E 10E 9H 10E 2C,9G
      ##STR827##
      0.4 9G 9H 9G 9G 5C,9G 5C,9H 5C,9H 1C,9G 10E 9H 10E 10E
      ##STR828##
      0.1 9H 9H 9G 9G 2C,7G 5C,9H 3C,9G 9G 5C,9G 9H 10E 5C,9H
      ##STR829##
      1.0 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR830##
      2.0 9C 9H 9G 10E 2C,9G 2C,9H 2C,9H 4C,9H 9H 9H 10E 5C,9H
      ##STR831##
      0.05 9G 9H 2G 2C,8G 1C 3C,8H 2C,5G 5G 1C,8G 2C,3G 8H 2C,3G
      ##STR832##
      0.05 8G 9H 4G 1C,8G 1C 9H,2C 2C,7G 2C,9G 2C,9H 8H 9H 1C,9G
      ##STR833##
      0.05 3G,9C 9H 5G 9G 2C,8G 9H 2C,8G 9H,2C 1C,9H 2C,6H 10E 7C,9H
      ##STR834##
      0.05 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR835##
      0.05 8G 9H 0 9G 2C 2C,8H 1C,5G 1C,5G 2C,7G 1C 9H 2C,9H
      ##STR836##
      0.05 2C,9G 9H 6G,2C 2C,9G 3C,7G 5C,9H 2C,9G 1C,9G 2C,8G 2C,6H 10E 9C,9H
      ##STR837##
      0.05 9G 9H 0 9G 1C 2C,3G 1C 4G 2C,7G 0 2C,8H 2C,9G
      ##STR838##
      0.05 1H 8H 1H 9G 1C 3C,4G 3G 5G 6G 1H 8H 1C,7G
      ##STR839##
      0.05 5G 8H 0 10E 7G 2C,8G 2G 9G 2C,9H 0 1oE 2C,9H
      ##STR840##
      20.05 6H0 6H0 00 00 2G0 00 00 00 00 00 1C0 2G0
      ##STR841##
      0.05 9H 9H 1C 8G 3C 3C,9H 2C 1C,4G 3C,7G 2G 2C,9H 2C,9H
      ##STR842##
      0.1 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR843##
      0.05 2G 9H 0 8G 0 7H 0 3G 2C,6G 0 3C,9H 9H
      ##STR844##
      2.0 6G 8H 0 0 0 4C 0 0 2C 0 0 2G
      ##STR845##
      0.4 8G 9H 2C 0 0 1C 0 0 2C 1C 5H 2C
      ##STR846##



      0.1 5G 5G 0 0 0 0 0 0 0 0 4G 2G
      ##STR847##
      0.1 9G 10E 8G 6G 3G 5G 0 4G 4G 9G 7G 6G
      ##STR848##
      0.1 9G 6G 8G 5G 1G 3G 2G 2G 2G 9G 7G 6G
      ##STR849##
      0.05 9G 7G 7G 9G 3G 3H,9G 6G 7G 9G 1G,2C 7G 9G
      ##STR850##
      0.05 3C,9G 9HZ 6G 10E 5G 2C,9H 2C,9G 2C,9G 1U,9H 9H 10E 10H
      ##STR851##
      0.05 9H -- 5G 10E 8G 2C,9H 2C,5G 9H 10E 1C,7H 10E 4C,9H
      ##STR852##
      0.05 8H 9H 4G 0 0 2C,6H 0 3G 1C,9G 1C,5H 10E 2C,9H
      ##STR853##
      0.05 10C -- 2C,9G 2C 1C 3C,9H 1C,4G 1C,4G 9G 2C,9H 10E 2C,9H
      ##STR854##
      50 5G 9H 0 4G 0 0 0 0 4G 0 2C,8G 3H
      ##STR855##
      0.05 7G 9G 3G 9G 0 2C 0 3G 1C,6G 0 2C,6G 2C
      ##STR856##
      0.05 8G 9H 4C,3G 10E 2C 3C,7H 1C,4G 1C,5G 2C,8H 2H 3C,7G 2C,9H
      ##STR857##
      0.05 9G 2C,9H 6G 2G 1C 0 0 0 1C,3G 1C,3G 1C 2C
      ##STR858##
      0.05 9G 9H 2C,6G 1C,7G 1C,4G 1C,3H 2C 0 2C,5G 2C,5H 2C,4G 1C,3G
      ##STR859##
      0.05 5G 3H 0 0 0 5H,2C 0 0 2G 0 2C,4G 2C,5G
      ##STR860##
      0.05 8H 9H 2C 10E 3G 2C,6G 2G 8G 8H 0 9H 3C,9H
      ##STR861##
      0.05 0 0 1C 0 2G 1C 0 0 2G 2G 5G 1C
      ##STR862##
      0.05 5C,3C 7H 2C 8G 1C,3G 2C,4G 1C 3G 1C,4G 2G 5C,9H 4C,8G
      ##STR863##
      0.05 1C 2G 0 0 0 0 0 0 0 0 0 0
      ##STR864##
      0.05 10E 10E 1C 5G 5G 5G 3G 4G 1C,4G 3G 3C,9H 3C,9H
      ##STR865##
      0.05 0 2G 0 0 0 2H 2G 2G 1C,2G 0 2G 1C,5G
      ##STR866##
      0.05 8G 9H 0 4G 1C 3C,9H 3G 2C,7G 9G 0 10E 1C,9G
      ##STR867##
      0.1 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR868##
      0.4 9H -- 7G 2C,7G 5C,9G 6C,9H 3C,9G 2C,9G 2C,9H 1C,2H 10E 5C,9H
      ##STR869##
      0.05 0 8H 0 0 0 0 0 0 2C,5G 0 7H 2C,8H
      ##STR870##
      0.05 9C 9H 9G 10E 5C,9G 5C,9H 2C,8G 10E 10E 3C,9H 10E 10E
      ##STR871##
      0.05 9C 9H 9G 10E 5C,9G 2C,9H 2C,9G 10E 10E 9H 10E 10E
      ##STR872##
      0.05 9C 9H 3C,9G 8G 5G 5C,9H 2C,4G 1C,6G 2C,9H 9H 10E 5C,9H
      ##STR873##
      2.0 0 0 0 0 0 0 0 0 0 0 0 0
      ##STR874##
      2.0 5G -- 1C 0 3G 0 0 0 0 0 0 0
      ##STR875##
      2.0 5G 8H 3H 0 1C 2C 0 0 2G 0 2C,5H 1C,3G


              TABLE B
    ______________________________________
    PRE-EMERGENCE ON FALLSINGTON SILT LOAM
    ______________________________________
     ##STR876##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      8G,7C     10E
    Barnyardgrass  7G,3H     8G,9C
    Sorghum        10E       10E
    Wild Oats      2G        5G
    Johnsongrass   7G,3H     8G,5H
    Dallisgrass    3G        4G
    Giant foxtail  8G,8C     9G,9C
    Ky. bluegrass  --        --
    Cheatgrass     8G        7G
    Sugarbeets     8G,6C     8G,7C
    Corn           5G,5H     7G,5H
    Mustard        8G,8C     9G,9C
    Cocklebur      6G,3H     6G,3H
    Pigweed        10C       10C
    Nutsedge       7G        8G
    Cotton         8G        8G
    Morningglory   7G        8G
    Cassia         3G        3G
    Teaweed        5G        6G
    Velvetleaf     6G,3H     7G,5C
    Jimsonweed     6G,6C     6G,6C
    Soybean        0         4G
    Rice           10E       10E
    Wheat          3G,3C     4G,3C
    ______________________________________
     ##STR877##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      7G,5C     10C
    Barnyardgrass  7G,6C     8G,9C
    Sorghum        10E       10E
    Wild Oats      5G        7G
    Johnsongrass   6G,5H     9G,8C
    Dallisgrass    7G        8G
    Giant foxtail  6G,3C     9G,3C
    Ky. bluegrass  --        --
    Cheatgrass     8G        10E
    Sugarbeets     8G,7C     8G,7C
    Corn           5G,5H     4G,3H
    Mustard        9G,9C     9G,9C
    Cocklebur      7G,4C     6G,5H
    Pigweed        9G,9C     10C
    Nutsedge       7G        9G
    Cotton         8G        8G
    Morningglory   7G        8G
    Cassia         3G        4G
    Teaweed        4G        5G,2C
    Velvetleaf     7C,7C     10C
    Jimsonweed     5G        5G,3C
    Soybean        0         6G,4C
    Rice           10E       10E
    Wheat          7G,4C     7G,4C
    ______________________________________
     ##STR878##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      3G        4G
    Barnyardgrass  3G        5G
    Sorghum        3G        5G,3H
    Wild Oats      0         0
    Johnsongrass   0         4G,3H
    Dallisgrass    3G        4G
    Giant foxtail  0         3G
    Ky. bluegrass  0         5G
    Cheatgrass     3G        5G
    Sugarbeets     0         3G
    Corn           2C        2C,2U
    Mustard        5G        7G
    Cocklebur      0         0
    Pigweed        3G        4G
    Nutsedge       0         0
    Cotton         0         3G
    Morningglory   3G        5G
    Cassia         0         0
    Teaweed        0         0
    Velvetleaf     0         0
    Jimsonweed     0         0
    Soybean        0         0
    Rice           5G,5C     7G,8C
    Wheat          0         3G
    ______________________________________
     ##STR879##
    Rate kg/ha     0.03      0.12      0.007
    ______________________________________
    Crabgrass      8G        9G,8C     6G
    Barnyardgrass  9G,7C     9G,7C     9G,7C
    Sorghum        10E       10E       8G,9C
    Wild Oats      6G,3H     8G,8C     6G,3H
    Johnsongrass   8G,3C     9G,9C     8G,5C
    Dallisgrass    --        --        5G
    Giant foxtail  6G,3H     9G,8C     3G
    Ky. bluegrass  7G,7C     8G,9C     7G
    Cheatgrass     10E       10E       10E
    Sugarbeets     9G,9C     9G,9C     7G,6C
    Corn           7G,5H     9G,9C     5G,2C
    Mustard        9G,9C     9G,9C     8G,8C
    Cocklebur      6G,3H     7G,5H     6G
    Pigweed        9G,8C     10E       10C
    Nutsedge       7G        6G        6G
    Cotton         7G        8G,3C     2G
    Morningglory   8G,3C     9G,8C     7G
    Cassia         7G        7G        5G
    Teaweed        6G        7G        2G
    Velvetleaf     8G,3C     10C       9G,5H
    Jimsonweed     7G        8G,4C     4G
    Soybean        4G        7G,5H     2G
    Rice           10E       10E       9G,9C
    Wheat          6G,3H     8G,8C     6G
    ______________________________________
     ##STR880##
    Rate kg/ha     0.03      0.12      0.007
    ______________________________________
    Crabgrass      8G        9G,8C     7G
    Barnyardgrass  9G,8C     9G,9C     9C,8G
    Sorghum        10E       10E       9G,9C
    Wild Oats      7G,3H     8G,6C     4G
    Johnsongrass   8G,3C     10C       8G,3C
    Dallisgrass    --        --        5G
    Giant foxtail  9G,5H     10C       5G,2C
    Ky. bluegrass  9G,9C     10C       8G
    Cheatgrass     10E       10E       10E
    Sugarbeets     9G,9C     9G,9C     7G,8C
    Corn           7G,5H     9G,9C     7G,3H
    Mustard        9G,9C     10C       7G,8C
    Cocklebur      6G        8G,5H     4G
    Pigweed        10E       10E       9G,9C
    Nutsedge       5G        7G        5G
    Cotton         7G,3H     9G,8C     4G,2H
    Morningglory   8G,3C     9G,6C     7G,3C
    Cassia         7G        7G        4G
    Teaweed        7G        7G,5C     4G
    Velvetleaf     8G,6C     10C       8G,5H
    Jimsonweed     7G,5C     9G,9C     4G
    Soybean        7G,5H     8G,5H     3G
    Rice           10E       10E       9G,9C
    Wheat          6G        8G,8C     5G
    ______________________________________
     ##STR881##
    Rate kg/ha     0.03      0.12      0.007
    ______________________________________
    Crabgrass      7G,3C     9G,9C     2G
    Barnyardgrass  6G,3C     7G,3C     4G
    Sorghum        8G,3C     10C       8G,3H
    Wild Oats      4G        6G        2G
    Johnsongrass   8G,4C     8G,4C     4G
    Dallisgrass    0         5G        0
    Giant foxtail  0         7G,3H     0
    Ky. bluegrass  8G,8C     8G,8C     0
    Cheatgrass     5G        7G,3H     3G
    Sugarbeets     9G,9C     10C       10C
    Corn           9G,7C     9G,9C     7G,3H
    Mustard        10C       10C       10C
    Cocklebur      8G,5H     9G,5H     6G
    Pigweed        9G,9C     10C       9G,9C
    Nutsedge       6G        6G        3G
    Cotton         8G,5H     8G,5H     6G,3H
    Morningglory   8G,3H     9G,5H     9G,8C
    Cassia         9G,8C     --        7G
    Teaweed        7G,3C     7G,3C     4G
    Velvetleaf     9G,9C     10C       8G
    Jimsonweed     6G,5C     7G,7C     5G
    Soybean        9G,5H     9G,5H     6G,3H
    Rice           10E       10E       6G
    Wheat          4G        4G        0
    ______________________________________
     ##STR882##
    Rate kg/ha     0.03      0.12      0.007
    ______________________________________
    Crabgrass      3G        6G,3C     0
    Barnyardgrass  5G        7G,4C     4G
    Sorghum        8G,3H     9G,9C     7G,3H
    Wild Oats      2G        4G        0
    Johnsongrass   5G,3H     7G,3H     5G
    Dallisgrass    0         6G        2G
    Giant foxtail  0         3G        0
    Ky. bluegrass  6G        8G,8C     3G
    Cheatgrass     0         7G        0
    Sugarbeets     10C       9G,9C     9G,9C
    Corn           6G,3H     6G,5H     2G,1U
    Mustard        10C       10C       10E
    Cocklebur      6G        7G,5H     6G
    Pigweed        8G,8C     10C       7G,5E
    Nutsedge       2G        7G        6G
    Cotton         6G,5H     9G,5H     6G,3H
    Morningglory   8G,3H     8G,3H     9G,8C
    Cassia         6G        --        4G
    Teaweed        6G,2C     7G,3C     3G
    Velvetleaf     8G,5H     8G,8C     6G
    Jimsonweed     5G        6G,3C     5G
    Soybean        5G        9G,5H     4G,3H
    Rice           7G        10E       5G
    Wheat          2G        2G        0
    ______________________________________
     ##STR883##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      0         0
    Barnyardgrass  3G        3G
    Sorghum        0         6G,3H
    Wild Oats      0         0
    Johnsongrass   0         5G,3H
    Dallisgrass    0         3G
    Giant foxtail  0         2H
    Ky. bluegrass  4G        6G
    Cheatgrass     0         10E
    Sugarbeets     3G        3G
    Corn           0         0
    Mustard        8G,5C     10C
    Cocklebur      0         0
    Pigweed        4G        8G,8C
    Nutsedge       0         7G
    Cotton         G         3G
    Morningglory   3G        4G
    Cassia         0         0
    Teaweed        0         3G
    Velvetleaf     5G,3H     6G,3H
    Jimsonweed     3G        5G
    Soybean        0         2G
    Rice           4G        5G,3H
    Wheat          0         0
    ______________________________________
     ##STR884##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      0         0
    Barnyardgrass  6G        6G,5H
    Sorghum        7G,3H     10C
    Wild Oats      3G        3G
    Johnsongrass   6G,3H     8G,5E
    Dallisgrass    0         4G
    Giant foxtail  0         3G
    Ky. bluegrass  7G,4C     7G,4C
    Cheatgrass     7G,5C     9G,9C
    Sugarbeets     6G,3H     10C
    Corn           4G,2U     6G,5H
    Mustard        10C       10C
    Cocklebur      2G        3G
    Pigweed        8G,8C     10C
    Nutsedge       7G        7G
    Cotton         5G        5G,2H
    Morningglory   5G        4G
    Cassia         5G        5G
    Teaweed        2G        4G
    Velvetleaf     8G,5H     9G,5H
    Jimsonweed     8G        8G
    Soybean        4G        4G
    Rice           7G        8G
    Wheat          4G        6G
    ______________________________________
     ##STR885##
    Rate kg/ha     0.03       0.12
    ______________________________________
    Crabgrass      8G,5C     9G,7C
    Barnyardgrass  9G,7C     9G,7C
    Sorghum        10E       10E
    Wild Oats      7G,3C     8G,5E
    Johnsongrass   9G,7C     9G,9C
    Dallisgrass    7G        8G
    Giant foxtail  7G,3H     9G,5H
    Ky. 


bluegrass  10C       9G,9C
    Cheatgrass     10C       10E
    Sugarbeets     9G,9C     9G,9C
    Corn           7G,5H     8G,3C
    Mustard        10C       10E
    Cocklebur      6G        7G
    Pigweed        10E       10E
    Nutsedge       8G        10E
    Cotton         3G        7G,5H
    Morningglory   6G        8G,3H
    Cassia         5G        7G
    Teaweed        6G        8G,4C
    Velvetleaf     8G,7C     10C
    Jimsonweed     6G        7G,7C
    Soybean        3G        6G,3H
    Rice           10E       10E
    Wheat          7G,3C     7G,5C
    ______________________________________
     ##STR886##
    Rate kg/ha     0.03      0.12      0.007
    ______________________________________
    Crabgrass      7G,3H     8G,5C     0
    Barnyardgrass  6G,3H     8G,4C     0
    Sorghum        9G,9C     10E       5G,3H
    Wild Oats      2G        7G,3H     0
    Johnsongrass   8G,5H     8G,5C     0
    Dallisgrass    6G        0         0
    Giant foxtail  5G,2H     7G,5H     0
    Ky. bluegrass  7G,7C     7G,5C     0
    Cheatgrass     7G,3C     10C       0
    Sugarbeets     9G,9C     9G.9C     5G,3H
    Corn           10C       10E       3G
    Mustard        10C       10C       7G,3C
    Cocklebur      7G,5H     8G,5H     2G
    Pigweed        10C       10C       5G
    Nutsedge       6G        7G        0
    Cotton         7G        8G,5H     0
    Morningglory   8G,3H     8G,3H     6G,5H
    Cassia         6G        --        0
    Teaweed        6G        7G,4C     0
    Velvetleaf     8G,8C     8G,8C     3G
    Jimsonweed     6G,4C     6G,5C     0
    Soybean        2H        7G,5H     0
    Rice           10E       10E       7G,3H
    Wheat          5G        6G        0
    ______________________________________
     ##STR887##
    Rate kg/ha     0.03      0.12
    ______________________________________
    Crabgrass      0         5G
    Barnyardgrass  5G,3H     4G,2H
    Sorghum        8G,5H     10C
    Wild Oats      0         3C
    Johnsongrass   7G,3H     8G,5H
    Dallisgrass    0         4G
    Giant foxtail  0         4H
    Ky. bluegrass  7G        8G,8C
    Cheatgrass     10E       10E
    Sugarbeets     6G,3H     10C
    Corn           5G,3H     6G,5H
    Mustard        8G,5C     10C
    Cocklebur      0         5G
    Pigweed        5G        10E
    Nutsedge       0         5G
    Cotton         3G        6G,3H
    Morningglory   4G        5G
    Cassia         3G        3G
    Teaweed        3G        4G,2C
    Velvetleaf     3H        6G,3H
    Jimsonweed     3G        7G,3C
    Soybean        0         4G,3H
    Rice           6G        7G,5H
    Wheat          3G        3G
    ______________________________________
     ##STR888##
    Rate kg/ha     0.12      0.5
    ______________________________________
    Crabgrass      0         0
    Barnyardgrass  0         0
    Sorghum        0         7G,5H
    Wild Oats      0         4G
    Johnsongrass   0         5G
    Dallisgrass    0         3G
    Giant foxtail  0         2G
    Ky. bluegrass  --        --
    Cheatgrass     0         5G
    Sugarbeets     2G        6G
    Corn           0         4G
    Mustard        8G,5C     10C
    Cocklebur      6G,3C     6G,2C
    Pigweed        4G,4C     7G,7C
    Nutsedge       0         5G
    Cotton         3G        7G
    Morningglory   0         6G
    Cassia         0         3G
    Teaweed        0         0
    Velvetleaf     4G,3C     5G
    Jimsonweed     0         0
    Soybean        0         4G,2H
    Rice           0         2G
    Wheat          0         3G
    ______________________________________
     ##STR889##
    Rate kg/ha     0.06      0.12      0.5
    ______________________________________
    Crabgrass      6G,7C     4G        7G
    Barnyardgrass  4G        6G        8G,4C
    Sorghum        9G,5C     9G,8C     10C
    Wild Oats      0         0         0
    Johnsongrass   4G,3H     4G        7G,3H
    Dallisgrass    0         0         3G
    Giant foxtail  3G        3G        6G,3C
    Ky. bluegrass  3G        3G        5G
    Cheatgrass     3G        --        --
    Sugarbeets     9G,9C     10C       10C
    Corn           5G        6G,3H     9G,5H
    Mustard        10C       8G        10C
    Cocklebur      6G,3H     7G,3H     8G,5H
    Pigweed        8G,8C     10C       10E
    Nutsedge       3G        7G        8G
    Cotton         8G,3H     9G,5C     9G,5C
    Morningglory   8G,3H     8G,3H     9G,9C
    Cassia         6G        5G        7G
    Teaweed        5G,3H     4G        8G,5C
    Velvetleaf     8G,7C     10C       10C
    Jimsonweed     9G,9C     7G        10C
    Soybean        0         3G        5G,3H
    Rice           10E       8G,6C     10E
    Wheat          0         0         0
    ______________________________________

                  TABLE C
    ______________________________________
           Post-emergence
                         Pre-emergence
    ______________________________________
            ##STR890##
    Rate kg/ha
             0.008           0.008
    wheat    1C,1G           0
    barley   1G              1G
    wild oats
             1C,1G           0
    downy brome
             2G              2G
    cheatgrass
             1C,4G           7G
    blackgrass
             3C,3G           5G
    annual   8C,8G           3C,6G
    bluegrass
    green foxtail
             1C,3G           1C,2G
    quackgrass
             2C,3G           3G
    Italian  6C,7G           1C,5G
    ryegrass
    ripgut brome
             1C,2G           0
    Russian  10C             3G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   10C             10C
    shepherd's
             10C             10C
    purse
    false    10C             6C,7G
    chamomile
    black    10C             7G
    nightshade
    yellow rocket
             10C             10C
    wild mustard
             10C             10C
    wild     10C             7C,6G
    buckwheat
    Rate kg/ha
             0.03            0.03
    wheat    6C,5G           0
    barley   2C,3G           2G
    wild oats
             7C,5G           0
    downy brome
             7C,7G           5C,7G
    cheatgrass
             10C             10C
    blackgrass
             9C,8G           7C,7G
    annual   10C             7C,8G
    bluegrass
    green foxtail
             10C             5C,6G
    quackgrass
             10C             2C,5G
    Italian  10C             5C,7G
    ryegrass
    ripgut brome
             3C,4G           1C,3G
    Russian  10C             7C,6G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   10C             10C
    shepherd's
             10C             10C
    purse
    false    10C             10C
    chamomile
    black    10C             7C,8G
    nightshade
    yellow rocket
             10C             10C
    wild mustard
             10C             10C
    wild     10C             7C,7G
    buckwheat
            ##STR891##
    Rate kg/ha
             0.015           0.015
    wheat    0               0
    barley   0               0
    wild oats
             0               2C,2G
    downy brome
             0               1C,3G
    cheatgrass
             0               1C,4G
    blackgrass
             0               3G
    annual   0               2G
    bluegrass
    green foxtail
             0               0
    quackgrass
             0               0
    Italian  0               0
    ryegrass
    ripgut brome
             0               0
    Russian  10C             0
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   10C             2C,5G
    shepherd's
             10C             10C
    purse
    false    10C             4C,6G
    chamomile
    black    0               2C,6G
    nightshade
    yellow rocket
             10C             3C,8G
    wild mustard
             10C             9C,9G
    wild     3C,2G           4G
    buckwheat
            ##STR892##
    Rate kg/ha
             0.06            0.06
    wheat    2G              0
    barley   0               0
    wild oats
             0               3C,4G
    downy brome
             0               4C,6G
    cheatgrass
             7C,5G           10C
    blackgrass
             7C,7G           10C
    annual   2G              3C,5G
    bluegrass
    green foxtail
             1C,3G           2C,4G
    quackgrass
             0               2C,3G
    Italian  0               0
    ryegrass
    ripgut brome
             0               0
    Russian  10C             7C,8G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   10C             7C,7G
    shepherd's
             10C             10C
    purse
    false    10C             7C,9G
    chamomile
    black    0               2C,7G
    nightshade
    yellow rocket
             10C             9C,9G
    wild mustard
             10C             10C
    wild     7C,6G           2C,7G
    buckwheat
            ##STR893##
    Rate kg/ha
             0.015           0.015
    wheat    0               0
    barley   0               0
    wild oats
             0               0
    downy brome
             0               2G
    cheatgrass
             0               1G
    blackgrass
             0               3G
    annual   0               2G
    bluegrass
    green foxtail
             0               0
    quackgrass
             0               0
    Italian  0               0
    ryegrass
    ripgut brome
             0               0
    Russian  10C             2C,2G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   2C,4G           3C,5G
    shepherd's
             10C             10C
    purse
    false    10C             7C,8G
    chamomile
    black    1C,3G           1C,8G
    nightshade
    yellow rocket
             2C,3G           5C,6G
    wild mustard
             10C             9C,9G
    wild     9C,8G           4C,7G
    buckwheat
    Rate kg/ha
             0.06            0.06
    wheat    0               0
    barley   0               0
    wild oats
             0               0
    downy brome
             2C,3G           2C,3G
    cheatgrass
             2C,5G           1C,5G
    blackgrass
             1C,3G           2C,7G
    annual   1C,4G           5G
    bluegrass
    green foxtail
             2G              2C,3G
    quackgrass
             0               1C,2G
    Italian  3G              3G
    ryegrass
    ripgut brome
             0               0
    Russian  10C             7C,8G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   7C,7G           7C,7G
    shepherd's
             10C             10C



    purse
    false    10C             9C,9G
    chamomile
    black    3C,6G           2C,8G
    nightshade
    yellow rocket
             10C             6C,8G
    wild mustard
             10C             9C,9G
    wild     10C             7C,7G
    buckwheat
            ##STR894##
    Rate kg/ha
             0.008           0.008
    wheat    0               0
    barley   0               0
    wild oats
             0               0
    downy brome
             0               1C,2G
    cheatgrass
             0               3G
    blackgrass
             1G              1C,3G
    annual   1G              5C,6G
    bluegrass
    green foxtail
             2G              0
    quackgrass
             0               2G
    Italian  0               4G
    ryegrass
    ripgut brome
             0               0
    Russian  10C             4C,5G
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   8C,8G           7C,8G
    shepherd's
             9C,8G           10C
    purse
    false    10C             7C,8G
    chamomile
    black    1G              2C,5G
    nightshade
    yellow rocket
             10C             10C
    wild mustard
             10C             10C
    wild     8C,7G           4C,7G
    buckwheat
    Rate kg/ha
             0.03            0.03
    wheat    0               0
    barley   0               0
    wild oats
             0               0
    downy brome
             1G              2C,5G
    cheatgrass
             2G              2C,5G
    blackgrass
             1C,3G           3C,7G
    annual   3G              5C,7G
    bluegrass
    green foxtail
             2C,3G           3G
    quackgrass
             1G              2C,7G
    Italian  2G              1G
    ryegrass
    ripgut brome
             0
    Russian  10C             10C
    thistle
    tansy mustard
             10C             10C
    smartweed
             --              --
    jimhill  10C             10C
    mustard
    Kochia   10C             8C,9G
    shepherd's
             10C             10C
    purse
    false    10C             9C,9G
    chamomile
    black    2C,3G           3C,8G
    nightshade
    yellow rocket
             10C             10C
    wild mustard
             10C             10C
    wild     10C             8C,8G
    buckwheat
    ______________________________________